Asymmetric dimethyl arginine levels in testicular tissue and blood of rats with induced experimental varicocele

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dc.contributor.authorAlan, Cabir
dc.contributor.authorErtung, Yunus
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorErsay, Ahmet Resit
dc.contributor.authorBasturk, Gokhan
dc.date.accessioned2025-01-27T20:47:31Z
dc.date.available2025-01-27T20:47:31Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Varicocele is one of the reasons for testicular dysfunction and is frequently known to accompany infertility. The basic pathology of varicocele is the development of endothelial dysfunction. The most important factors in development of endothelial dysfunction are impaired endothelial-linked vasodilatation, increase in free oxygen radicals, reduced synthesis and release of nitric oxide (NO), abnormal vasoconstriction and increased levels of dimethyl arginine. Our aim was to identify and illustrate the relationship between asymmetric dimethyl arginine (ADMA) and NO levels in testicular tissue and plasma of rats with induced experimental varicocele. Materials and methods: Twenty-one adolescent (average 6 weeks) male rats were included in the study and randomly divided into 3 groups. Group 1 (control, n=6) did not undergo any procedure. Group 2 (sham, n=6) had the left renal vein circled proximally but ligation was not performed. Group 3 (varicocele-induced, n=9) had partial ligation of the proximal left renal vein to induce left varicocele. Superoxide dismutase (SOD) enzyme activity and levels of end-products of NO, nitrite and nitrate salts were investigated in testis tissue. Nitrite/nitrate and ADMA levels were investigated in plasma. Histopathological examination was completed with routine hematoxylin-eosine and TUNEL dyes. Results: Tissue SOD and plasma ADMA values were clearly increased in the varicocele group compared to the other groups; tissue and plasma nitrite/nitrate levels were clearly reduced in the varicocele group and this was observed to be statistically significant between the groups. Conclusion: We believe our study has opened an important window on the relationship between infertility observed in varicocele patients and ADMA. We believe that broad-series prospective studies to support this are required. (C) 2014 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.
dc.identifier.doi10.1016/j.androl.2014.04.007
dc.identifier.endpage144
dc.identifier.issn1698-031X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84912533789
dc.identifier.scopusqualityQ3
dc.identifier.startpage139
dc.identifier.urihttps://doi.org/10.1016/j.androl.2014.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24944
dc.identifier.volume12
dc.identifier.wosWOS:000345555000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Espana Slu
dc.relation.ispartofRevista Internacional De Andrologia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAsymmetric dimethyl arginine
dc.subjectVaricocele
dc.subjectTestes
dc.titleAsymmetric dimethyl arginine levels in testicular tissue and blood of rats with induced experimental varicocele
dc.typeReview Article

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