Screening autonomic functions in patients with restless legs syndrome: A case-control study in a tertiary care hospital

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dc.authorscopusid57044442800en_US
dc.authorwosid-en_US
dc.contributor.authorBaşaran, Şehnaz
dc.contributor.authorAkıncı, Erhan
dc.date.accessioned2025-02-06T09:21:58Z
dc.date.available2025-02-06T09:21:58Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The clinical importance of autonomic involvement in patients with restless legs syndrome (RLS) remains unclear. To our knowledge, no study has explored the relationship between autonomic dysfunction and disease-related variables in patients with RLS. Therefore, this study aimed 1) to determine the presence of autonomic symptoms in drug-naïve patients with RLS in comparison with healthy controls using Scales for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT) questionnaire and 2) to evaluate the possible associations of autonomic dysfunction with clinical factors in RLS. Methods: A total of 70 drug-naïve patients with RLS and 85 healthy volunteers were enrolled. The SCOPA-AUT questionnaire and Epworth Sleepiness Scale (ESS) scores were used to determine autonomic functions and sleep propensity, respectively. Moreover, the International Restless Legs Syndrome Study Group rating scale was used to evaluate disease severity in the patient group. Results: Compared with the control group, the RLS group had significantly higher subscale scores (gastrointestinal, urinary, cardiovascular, thermoregulatory, pupillomotor, and sexual [women]) and total scores of the SCOPA-AUT questionnaire (p < 0.05). In the patient group, there was a significant correlation between the total scores and subscale scores (gastrointestinal, cardiovascular, and thermoregulatory subscales) of the SCOPA-AUT questionnaire and disease severity. Moreover, ESS was positively correlated with the total scores and subscale scores (urinary, cardiovascular, and pupillomotor) of the SCOPA-AUT questionnaire. Conclusion: Disease severity and daytime sleepiness may be related to autonomic dysfunction in RLS. Further studies focusing on autonomic functions in RLS are required to improve management strategies and clinical outcomes.en_US
dc.identifier.citationBaşaran, S., & Akıncı, E. (2022). Screening autonomic functions in patients with restless legs syndrome: A case-control study in a tertiary care hospital. Autonomic Neuroscience, 237. https://doi.org/10.1016/j.autneu.2021.102924en_US
dc.identifier.doi10.1016/j.autneu.2021.102924en_US
dc.identifier.endpage7en_US
dc.identifier.issn1566-0702 / 1872-7484
dc.identifier.pmidPMID: 34871924en_US
dc.identifier.scopus2-s2.0-85120495446en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.autneu.2021.102924
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29556
dc.identifier.volume237en_US
dc.identifier.wosWOS:000819810000013en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkıncı, Erhan
dc.institutionauthorid0000-0003-3331-8165
dc.language.isoengen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofAutonomic Neuroscience: Basic and Clinicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutonomic dysfunctionen_US
dc.subjectDysautonomiaen_US
dc.subjectRestless legs syndromeen_US
dc.subjectSCOPA-AUTen_US
dc.titleScreening autonomic functions in patients with restless legs syndrome: A case-control study in a tertiary care hospitalen_US
dc.typearticleen_US

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