A new organ preservation solution for static cold storage of the liver. Amniotic fluid

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dc.authoridAdali, Yasemen/0000-0002-8004-7364
dc.contributor.authorBuyuk, Basak
dc.contributor.authorDemirci, Tuba
dc.contributor.authorAdali, Yasemen
dc.contributor.authorEroglu, Huseyin Avni
dc.date.accessioned2025-01-27T20:41:04Z
dc.date.available2025-01-27T20:41:04Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To evaluate the effect of amniotic fluid in liver preservation in organ transplantation, and compare it with standard preservation solutions. Methods: The groups consisted of Group 1: Ringer Lactate (RL) group, Group 2: HTK group, Group 3: UW group, Group 4: AF group. The livers of rats from Group 1, 2, 3, and 4 were perfused and placed into falcon tubes containing RL, HTK, UW, and AF solutions at +4(sic)degrees C, respectively. The tubes were stored for 12 hours in the refrigerator at +4 degrees C. Tissue samples were taken at the 6th and 12th hours for histopathological examinations of the perfused livers, and storage solutions for biochemical analyzes at 6th and 12th hours. Results: AF was shown to maintain organ viability by reducing the number of cells undergoing apoptosis. Histopathological changes such as sinusoidal dilatation, hydropic degeneration, and focal necrosis were found to be similar to the groups in which the standard organ preservation solutions were used. Additionally, the results of INOS, IL-10, and TNF-alpha, which were evaluated immunohistochemically, have been shown to be similar to the UW and HTK groups. Conclusions: AF provided conservation similar to UW and HTK in the 12-hour liver SCS process. The fact that apoptosis values are comparable to standard preservation solutions supports the success of AF in the cold storage of the liver.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [216S238]
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey (TUBITAK) (Project number: 216S238)
dc.identifier.doi10.1590/s0102-865020190040000002
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue4
dc.identifier.pmid31038582
dc.identifier.scopus2-s2.0-85065500013
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/s0102-865020190040000002
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23995
dc.identifier.volume34
dc.identifier.wosWOS:000466608300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectLiver Transplantation
dc.subjectAmniotic Fluid
dc.subjectPathology
dc.subjectApoptosis
dc.subjectRats
dc.titleA new organ preservation solution for static cold storage of the liver. Amniotic fluid
dc.typeArticle

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