Comparison of Effects of Alpha Receptor Blockers on Endothelial Functions and Coagulation Parameters in Patients with Benign Prostatic Hyperplasia

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dc.authoridAlan, Cabir/0000-0002-6024-4475
dc.contributor.authorAlan, Cabir
dc.contributor.authorKirilmaz, Bahadir
dc.contributor.authorKocoglu, Hasan
dc.contributor.authorErsay, Ahmet Resit
dc.contributor.authorErtung, Yunus
dc.contributor.authorEren, Ali Erhan
dc.date.accessioned2025-01-27T21:05:25Z
dc.date.available2025-01-27T21:05:25Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOBJECTIVE To investigate the effects of alpha receptor blockers used in the treatment of benign prostatic hyperplasia (BPH) on endothelial functions, coagulation parameters, and arterial blood pressure. MATERIALS AND METHODS One-hundred fifteen patients admitted to the treatment protocol because of symptomatic BPH were included in this prospective study. Patients were given the following treatments: doxazosin 4 mg/d (n = 25), terazosin 5 mg/d (n = 26), alfuzosin 10 mg/d (n = 26), tamsulosin 0.4 mg/d (n = 21), and observation (n = 17). All cases were evaluated before treatment and in the 12th week of treatment, according to biochemical parameters, endothelial functions, and arterial blood pressure. Biochemical parameters were bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time, total prostate-specific antigen (PSA), and free PSA. Endothelial functions were evaluated with ultrasonography of the brachial artery. RESULTS When coagulation tests were evaluated, there were significant increases in bleeding and coagulation times in the groups using doxazosin and terazosin. Doxazosin and terazosin lowered arterial blood pressure significantly compared with other treatments. With regard to effects on endothelial function, there were significant differences in flow-mediated dilation rates of the brachial artery at 60 and 90 seconds before and during treatment in the alfuzosin and terazosin groups. CONCLUSIONS Alpha receptor blockers can decrease the risk of cardiovascular complications by both reducing platelet aggregation and protecting endothelial functions in patients with prostatic hyperplasia. The only drug with a favorable effect in all 4 areas of interest, including BPH symptoms, blood pressure, platelet aggregation, and endothelial functions, was terazosin. UROLOGY 77: 1439-1443, 2011. (C) 2011 Elsevier Inc.
dc.identifier.doi10.1016/j.urology.2010.10.019
dc.identifier.endpage1443
dc.identifier.issn0090-4295
dc.identifier.issue6
dc.identifier.pmid21256572
dc.identifier.scopus2-s2.0-79957895867
dc.identifier.scopusqualityQ2
dc.identifier.startpage1439
dc.identifier.urihttps://doi.org/10.1016/j.urology.2010.10.019
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27630
dc.identifier.volume77
dc.identifier.wosWOS:000291047500052
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofUrology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectVitro Platelet-Aggregation
dc.subjectLower Urinary-Tract
dc.subjectHypertension
dc.subjectDoxazosin
dc.subjectHypertrophy
dc.subjectUltrasound
dc.subjectArtery
dc.titleComparison of Effects of Alpha Receptor Blockers on Endothelial Functions and Coagulation Parameters in Patients with Benign Prostatic Hyperplasia
dc.typeArticle

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