The effect of aloe vera on ischemia-Reperfusion injury of sciatic nerve in rats

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dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorGuven, Mustafa
dc.contributor.authorGolge, Umut Hatay
dc.contributor.authorAslan, Esra
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.contributor.authorCosar, Murat
dc.date.accessioned2025-01-27T20:47:27Z
dc.date.available2025-01-27T20:47:27Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: Aloe vera is compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of aloe vera treatment in rats with experimental sciatic nerve ischemia/reperfusion injury. Methods: Twenty-eight male Wistar Albino rats were divided equally into 4 groups. Groups; Control group (no surgical procedure or medication), sciatic nerve ischemia/reperfusion group, sciatic nerve ischemia/reperfusion + aloe vera group and sciatic nerve ischemia/reperfusion + methylprednisolone group. Ischemia was performed by clamping the infrarenal abdominal aorta. 24 hours after ischemia, all animals were sacrificed. Sciatic nerve tissues were also examined histopathologically and biochemically. Results: Ischemic fiber degeneration significantly decreased in the pre-treated with aloe vera and treated with methylprednisolone groups, especially in the pre-treated with aloe vera group, compared to the sciatic nerve ischemia/reperfusion group (p < 0.05). A significant decrease in MDA, an increase in NRF1 level and SOD activity were observed in the groups which obtained from the AV and MP groups when compared to the sciatic nerve ischemia/reperfusion group. When all results were analysed it was seen that the aloe vera group was not statistically different compared to the MP group (p > 0.05). Conclusions: Aloe vera is effective neuroprotective against sciatic nerve ischemia/reperfusion injury via antioxidant and anti-inflammatory properties. Also aloe vera was found to be as effective as MP. (C) 2016 Elsevier Masson SAS. All rights reserved.
dc.identifier.doi10.1016/j.biopha.2016.02.023
dc.identifier.endpage207
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid27044829
dc.identifier.scopus2-s2.0-84960385083
dc.identifier.scopusqualityQ1
dc.identifier.startpage201
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2016.02.023
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24912
dc.identifier.volume79
dc.identifier.wosWOS:000373527100025
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAloe
dc.subjectIschemia
dc.subjectRats
dc.subjectReperfusion injury
dc.subjectSciatic nerve
dc.titleThe effect of aloe vera on ischemia-Reperfusion injury of sciatic nerve in rats
dc.typeArticle

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