Protective Effect of Hesperetin and Naringenin against Apoptosis in Ischemia/Reperfusion-Induced Retinal Injury in Rats

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dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.contributor.authorKara, Selcuk
dc.contributor.authorGencer, Baran
dc.contributor.authorKaraca, Turan
dc.contributor.authorTufan, Hasan Ali
dc.contributor.authorArikan, Sedat
dc.contributor.authorErsan, Ismail
dc.contributor.authorKaraboga, Ihsan
dc.date.accessioned2025-01-27T20:31:39Z
dc.date.available2025-01-27T20:31:39Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose. Hesperetin and naringenin are naturally common flavonoids reported to have antioxidative effects. This study was performed to investigate whether either hesperetin or naringenin has a protective effect against apoptosis on retinal ischemia/reperfusion (I/R) injury. Methods. Retinal I/R was induced by increasing the intraocular pressure to 150 mm Hg for 60 minutes. Thirty-three male Wistar albino rats were randomised into 5 groups named control, I/R + sham, I/R + solvent (DMSO), I/R + hesperetin, and I/R + naringenin. Animals were given either hesperetin, naringenin, or the solvent intraperitoneally immediately following reperfusion. Thickness of retinal layers and retinal cell apoptosis were detected by histological analysis, tunel assay, and immunohistochemistry assay. Results. Hesperetin and naringenin attenuated the I/R-induced apoptosis of retinal cells in the inner and outer nuclear cells of the rat retina. Retinal layer thickness of the naringenin treatment group was significantly thicker than that of the hesperetin, sham, and solvent groups (P < 0.05). Conclusions. Hesperetin and naringenin can prevent harmful effects induced by I/R injury in the rat retina by inhibiting apoptosis of retinal cells, which suggests that those flavanones have a therapeutic potential for the protection of ocular ischemic diseases.
dc.identifier.doi10.1155/2014/797824
dc.identifier.issn1537-744X
dc.identifier.pmid24616645
dc.identifier.scopus2-s2.0-84898803130
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2014/797824
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23226
dc.identifier.wosWOS:000330893000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofScientific World Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectFunction Recovery
dc.subjectCitrus Flavonone
dc.subjectGanglion-Cells
dc.subjectIschemia
dc.subjectReperfusion
dc.subjectAntioxidant
dc.subjectFlavanone
dc.subjectSurvival
dc.subjectEfficacy
dc.subjectInsult
dc.titleProtective Effect of Hesperetin and Naringenin against Apoptosis in Ischemia/Reperfusion-Induced Retinal Injury in Rats
dc.typeArticle

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