Brucellosis in pregnancy: results of multicenter ID-IRI study

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dc.authoridERBAY, AYSE/0000-0001-8882-4124
dc.authoridSahin, Suzan/0000-0002-7124-3363
dc.authoridHaykir Solay, Asli/0000-0002-1326-9776
dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.authoridDemirdal, Tuna/0000-0002-9046-5666
dc.authoridKarahocagil, Mustafa Kasim/0000-0002-5171-7306
dc.authoridBeeching, Nicholas/0000-0002-7019-8791
dc.contributor.authorInan, Asuman
dc.contributor.authorErdem, Hakan
dc.contributor.authorElaldi, Nazif
dc.contributor.authorGulsun, Serda
dc.contributor.authorKarahocagil, Mustafa K.
dc.contributor.authorPekok, Abdullah U.
dc.contributor.authorUlug, Mehmet
dc.date.accessioned2025-01-27T20:44:01Z
dc.date.available2025-01-27T20:44:01Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBrucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p<0.001), vaginal bleeding (p<0.001), anemia (blood hemoglobin <11g/dL; p<0.001), high level of serum aspartate aminotransferase (>41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area.
dc.identifier.doi10.1007/s10096-019-03540-z
dc.identifier.endpage1268
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue7
dc.identifier.pmid30989418
dc.identifier.scopus2-s2.0-85064538124
dc.identifier.scopusqualityQ1
dc.identifier.startpage1261
dc.identifier.urihttps://doi.org/10.1007/s10096-019-03540-z
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24454
dc.identifier.volume38
dc.identifier.wosWOS:000471726700008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPregnancy
dc.subjectBrucellosis
dc.subjectObstetrics
dc.subjectAbortus
dc.subjectIntrauterine fetal demise
dc.subjectRisk factors
dc.titleBrucellosis in pregnancy: results of multicenter ID-IRI study
dc.typeArticle

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