The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis

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dc.contributor.authorGul, Ceren
dc.contributor.authorKilic, Sevilay
dc.contributor.authorSehitoglu, Muserref Hilal
dc.date.accessioned2025-01-27T20:47:22Z
dc.date.available2025-01-27T20:47:22Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation. Aim To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs). Methods In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P < 0.05 was considered statistically significant. Results The mean values for serum ADAM10 and ADAM17 were, respectively, 3.1 +/- 2.2 and 76.5 +/- 31.1 in the psoriasis group and 8.6 +/- 3.7 and 29.5 +/- 22.4 in the HC group. A statistically significant difference between the patient and HC groups was detected for both ADAM10 and ADAM17 levels (P = 0.001). Conclusion Considering the high levels of ADAM17 in the psoriasis group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributable to its regulatory effect on keratinocyte differentiation and proliferation.
dc.identifier.doi10.1111/ced.15239
dc.identifier.endpage1678
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue9
dc.identifier.pmid35474465
dc.identifier.scopus2-s2.0-85132325515
dc.identifier.scopusqualityQ2
dc.identifier.startpage1673
dc.identifier.urihttps://doi.org/10.1111/ced.15239
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24865
dc.identifier.volume47
dc.identifier.wosWOS:000814210100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical and Experimental Dermatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNecrosis-Factor-Alpha
dc.subjectConverting Enzyme
dc.subjectOverexpression
dc.subjectMigration
dc.titleThe importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis
dc.typeArticle

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