The Neuroprotective Effect of Kefir on Spinal Cord Ischemia/Reperfusion Injury in Rats

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dc.contributor.authorGuven, Mustafa
dc.contributor.authorAkman, Tarik
dc.contributor.authorYener, Ali Umit
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorYuksel, Yasemin
dc.contributor.authorCosar, Murat
dc.date.accessioned2025-01-27T20:41:02Z
dc.date.available2025-01-27T20:41:02Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective : The main causes of spinal cord ischemia are a variety of vascular pathologies causing acute arterial occlusions. We investigated neuroprotective effects of kefir on spinal cord ischemia injury in rats. Methods : Rats were divided into three groups : 1) sham operated control rats; 2) spinal cord ischemia group fed on a standard diet without kefir pretreatment; and 3) spinal cord ischemia group fed on a standard diet plus kefir. Spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. The spinal cord was removed after the procedure. The biochemical and histopathological changes were observed within the samples. Functional assessment was performed for neurological deficit scores. Results : The kefir group was compared with the ischemia group, a significant decrease in malondialdehyde levels was observed (p<0.05). Catalase and superoxide dismutase levels of the kefir group were significantly higher than ischemia group (p<0.05). In histopathological samples, the kefir group is compared with ischemia group, there was a significant decrease in numbers of dead and degenerated neurons (p<0.05). In immunohistochemical staining, hipoxia-inducible factor-1 alpha and caspase 3 immunopositive neurons were significantly decreased in kefir group compared with ischemia group (p<0.05). The neurological deficit scores of kefir group were significantly higher than ischemia group at 24 h (p<0.05). Conclusion : Our study revealed that kefir pretreatment in spinal cord ischemia/reperfusion reduced oxidative stress and neuronal degeneration as a neuroprotective agent. Ultrastructural studies are required in order for kefir to be developed as a promising therapeutic agent to be utilized for human spinal cord ischemia in the future.
dc.identifier.doi10.3340/jkns.2015.57.5.335
dc.identifier.endpage341
dc.identifier.issn2005-3711
dc.identifier.issn1598-7876
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84931057329
dc.identifier.scopusqualityQ2
dc.identifier.startpage335
dc.identifier.urihttps://doi.org/10.3340/jkns.2015.57.5.335
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23984
dc.identifier.volume57
dc.identifier.wosWOS:000356206200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherKorean Neurosurgical Soc
dc.relation.ispartofJournal of Korean Neurosurgical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSpinal cord ischemia
dc.subjectCultured milk products
dc.subjectReperfusion injury
dc.titleThe Neuroprotective Effect of Kefir on Spinal Cord Ischemia/Reperfusion Injury in Rats
dc.typeArticle

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