Beyond traditional dentistry: How organoids and next-gen hydrogels are redesigning dental tissue regeneration

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dc.authorid0000-0003-0412-2868
dc.authorid0000-0003-3445-1814
dc.contributor.authorYilmaz-Dagdeviren, Hilal Deniz
dc.contributor.authorArslan, Yavuz Emre
dc.date.accessioned2026-02-03T12:02:48Z
dc.date.available2026-02-03T12:02:48Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDental tissue regeneration has advanced rapidly with the development of bioengineered hydrogels and organoid technologies. In this review, multifunctional hydrogels are examined as biomimetic platforms with osteoinductive, adhesive, angiogenic, antimicrobial, and immunomodulatory properties tailored to enamel, dentin-pulp complex, periodontal ligament, and alveolar bone repair. Incorporation of bioactive molecules, including growth factors, bioceramics, antioxidants, and immune-modulating agents, has been reported to enhance tissue-specific regeneration while mitigating infection and inflammation. Stimuli-responsive designs have been utilized to enable spatiotemporally controlled delivery and degradation. Immunomodulatory hydrogels also have been shown to direct macrophage polarization, regulate T-cell infiltration, and promote matrix remodeling. Furthermore, organoid models supported by hydrogels have been employed to replicate dental tissue architecture, guide lineage-specific differentiation, and provide reproducible, physiologically relevant platforms for drug screening and developmental studies. Emerging strategies such as microfluidic organoid-on-chip systems and mechanically stimulated cultures are noted for their potential to provide more physiologically relevant models. Early clinical studies involving hydrogel-based scaffolds and stem cell constructs are discussed, indicating growing translational potential. Overall, these developments highlights that how advanced hydrogels and organoid systems can contribute to a shift from conventional restorative methods toward tissue engineering-based regenerative therapies.
dc.identifier.doi10.1016/j.bioadv.2025.214494
dc.identifier.issn2772-9508
dc.identifier.pmid40934753
dc.identifier.scopus2-s2.0-105015301916
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.bioadv.2025.214494
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34874
dc.identifier.volume179
dc.identifier.wosWOS:001582160300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBiomaterials Advances
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectDental regeneration
dc.subjectHydrogels
dc.subjectDental tissue engineering
dc.subjectOrganoids
dc.subjectClinical translation
dc.titleBeyond traditional dentistry: How organoids and next-gen hydrogels are redesigning dental tissue regeneration
dc.typeReview

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