Single, Double, and Multiple-Heteroatoms Doped Carbon Quantum Dots as Effective Light-Induced Antimicrobial Materials

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dc.authoridSağbaş, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorDemirci, Şahin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2026-02-03T12:03:01Z
dc.date.available2026-02-03T12:03:01Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSingle-, dual-, and multi-heteroatoms such as N, S, and B-doped carbon quantum dots (CQ-dots) were prepared to determine their dopant effects on anti-pathogenic activities. The CQ-dots were prepared using maleic acid (MA), poly(vinyl amine) (PVAm), cysteine (Cys), and boric acid (BA) as carbon, nitrogen, sulfur, and boron sources, respectively. In 345–415 nm emission wavelength range, 45.9 ± 2.4% quantum yield for dual heteroatom-doped (N/B-doped) CQ-dots were attained. Antimicrobial studies revealed that N-doped CQ-dots have significant antimicrobial susceptibility to both bacteria and fungi. The zeta potential value of N-doped CQDs had -4.9 mV was changed to -9.2 and -11.5 mV upon N/S- and N/B-doping, respectively. N/B-doped CQ-dots afforded the highest antibacterial activity providing a 1.56 mg/mL minimum inhibitory concentration (MIC) value against Escherichia coli, whereas N/S-doped CQ-dots had the highest antimicrobial activity against Staphylococcus aureus and Candida albicans yeast, 0.37 mg/mL MIC values. The photodynamic antimicrobial studies of N-, N/S-, N/B-, and N/S/B-doped CQ-dots significantly eradicated the bacteria and fungus colony upon UV-A light exposure for 30 min, with > 50% microbial colonial inhibitions. Both N and N/S-doped CQ-dots exhibit higher biofilm eradication/inhibition efficacy on Candida albicans biofilm, and all CQ-dots are biocompatible according to blood compatibility and cytotoxicity analysis at 1000 μg/mL.
dc.description.sponsorshipCanakkale Onsekiz Mart University [FIA-2022-3667]
dc.description.sponsorshipScientific Research Commission of Canakkale Onsekiz Mart University
dc.description.sponsorshipThis work is supported by the Scientific Research Commission of Canakkale Onsekiz Mart University FIA-2022-3667.
dc.identifier.doi10.1007/s10895-025-04589-0
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.pmid41105182
dc.identifier.scopus2-s2.0-105019229190
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10895-025-04589-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34937
dc.identifier.wosWOS:001597011400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofJournal of Fluorescence
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectCarbon quantum dots (CQ-dots)
dc.subjectAntimicrobial
dc.subjectPhotodynamic antipathogenic material
dc.subjectAntibiofilm
dc.subjectBiocompatible
dc.titleSingle, Double, and Multiple-Heteroatoms Doped Carbon Quantum Dots as Effective Light-Induced Antimicrobial Materials
dc.typeArticle

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