Single, Double, and Multiple-Heteroatoms Doped Carbon Quantum Dots as Effective Light-Induced Antimicrobial Materials

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dc.contributor.authorSuner, Selin Sagbas
dc.contributor.authorSahiner, Mehtap
dc.contributor.authorDemirci, Sahin
dc.contributor.authorSahiner, Nurettin
dc.date.accessioned2026-02-03T12:03:01Z
dc.date.available2026-02-03T12:03:01Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSingle-, dual-, and multi-heteroatoms such as N, S, and B-doped carbon quantum dots (CQ-dots) were prepared to determine their dopant effects on anti-pathogenic activities. The CQ-dots were prepared using maleic acid (MA), poly(vinyl amine) (PVAm), cysteine (Cys), and boric acid (BA) as carbon, nitrogen, sulfur, and boron sources, respectively. In 345-415 nm emission wavelength range, 45.9 +/- 2.4% quantum yield for dual heteroatom-doped (N/B-doped) CQ-dots were attained. Antimicrobial studies revealed that N-doped CQ-dots have significant antimicrobial susceptibility to both bacteria and fungi. The zeta potential value of N-doped CQDs had -4.9 mV was changed to -9.2 and -11.5 mV upon N/S- and N/B-doping, respectively. N/B-doped CQ-dots afforded the highest antibacterial activity providing a 1.56 mg/mL minimum inhibitory concentration (MIC) value against Escherichia coli, whereas N/S-doped CQ-dots had the highest antimicrobial activity against Staphylococcus aureus and Candida albicans yeast, 0.37 mg/mL MIC values. The photodynamic antimicrobial studies of N-, N/S-, N/B-, and N/S/B-doped CQ-dots significantly eradicated the bacteria and fungus colony upon UV-A light exposure for 30 min, with > 50% microbial colonial inhibitions. Both N and N/S-doped CQ-dots exhibit higher biofilm eradication/inhibition efficacy on Candida albicans biofilm, and all CQ-dots are biocompatible according to blood compatibility and cytotoxicity analysis at 1000 mu g/mL.
dc.description.sponsorshipCanakkale Onsekiz Mart University [FIA-2022-3667]
dc.description.sponsorshipScientific Research Commission of Canakkale Onsekiz Mart University
dc.description.sponsorshipThis work is supported by the Scientific Research Commission of Canakkale Onsekiz Mart University FIA-2022-3667.
dc.identifier.doi10.1007/s10895-025-04589-0
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.pmid41105182
dc.identifier.scopus2-s2.0-105019229190
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s10895-025-04589-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34937
dc.identifier.wosWOS:001597011400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofJournal of Fluorescence
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectCarbon quantum dots (CQ-dots)
dc.subjectAntimicrobial
dc.subjectPhotodynamic antipathogenic material
dc.subjectAntibiofilm
dc.subjectBiocompatible
dc.titleSingle, Double, and Multiple-Heteroatoms Doped Carbon Quantum Dots as Effective Light-Induced Antimicrobial Materials
dc.typeArticle

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