The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

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dc.authoridYüksel, Selçuk / 0000-0001-9415-1640
dc.contributor.authorAksu, Bağdagül
dc.contributor.authorAfonso, Alberto Caldas
dc.contributor.authorAkıl, İpek
dc.contributor.authorAlpay, Harika
dc.contributor.authorAtmış, Bahriye
dc.contributor.authorAydoğ, Özlem
dc.contributor.authorBakkaloğlu, Sevcan
dc.contributor.authorYüksel, Selçuk
dc.date.accessioned2025-01-27T20:34:58Z
dc.date.available2025-01-27T20:34:58Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes. Methods: Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05). Conclusion: Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [29652]; European Society for Pediatric Nephrology (ESPN) [5.2018]; Society for Children's Kidney Health [1.2018]; Istanbul Faculty of Medicine Foundation
dc.description.sponsorshipThe author(s) declare financial support was received for the research, authorship, and/or publication of this article. UTILISE Study was supported by Scientific Research Projects Coordination Unit of Istanbul University (29652), by the European Society for Pediatric Nephrology (ESPN) (ESPN #5.2018), by the Society for Children's Kidney Health (1.2018), and by Istanbul Faculty of Medicine Foundation.
dc.identifier.doi10.3389/fruro.2023.1281081
dc.identifier.issn2673-9828
dc.identifier.pmidPMID: 40778050
dc.identifier.scopus2-s2.0-85187893854
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.3389/fruro.2023.1281081
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23528
dc.identifier.volume3
dc.identifier.wosWOS:001376826000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Urology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectchildren
dc.subjectcongenital anomalies of the kidney and urinary tract
dc.subjectCAKUT
dc.subjectheat shock proteins
dc.subjectHsp70
dc.subjectUTILISE study
dc.titleThe relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study
dc.typeArticle

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