A comparative toxicity study between small and large size zinc oxide nanoparticles in tilapia (Oreochromis niloticus): Organ pathologies, osmoregulatory responses and immunological parameters

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dc.authoridGurkan, Mert/0000-0001-7861-3999
dc.authoridKaya, Hasan/0000-0003-0330-2453
dc.contributor.authorKaya, Hasan
dc.contributor.authorAydin, Fatih
dc.contributor.authorGurkan, Mert
dc.contributor.authorYılmaz, Sevdan
dc.contributor.authorAtes, Mehmet
dc.contributor.authorDemir, Veysel
dc.contributor.authorArslan, Zikri
dc.date.accessioned2025-01-27T21:02:06Z
dc.date.available2025-01-27T21:02:06Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTilapia (Oreochromis niloticus) was exposed to different sizes of zinc oxide nanoparticles (ZnO-NPs) to evaluate their organ pathologies (kidney, liver, gill, and intestine), osmoregulatory responses and immunological parameters. Sub-chronic exposure was conducted in fresh water with 1 and 10 mg/L concentrations of the small (10-30 nm) and large-size ZnO (100 nm) particles for 7 and 14 days. In this study, it is found that small and large forms of ZnO-NPs cause various pathologic findings in the target organs at all concentrations. These findings are increased of melanomacrophage aggregates, tubular deformations, necrosis and cytoplasmic vacuolations in the kidney, oedema, mononuclear cell infiltrations, fatty changes, pyknotic nuclei and hepatocellular vacuolations in the liver, hyperplasia, aneurysms, and epithelial liftings in the gills, and hyperplasia, swelled of goblet cells, villus deformations in the intestine. Results showed that respiratory burst and potential killing activity at the small-size ZnO concentration significantly increased compared to the control group (p < 0.05) but significant reductions of these parameters at the large-size ZnO concentrations compared to control (p < 0.05) were measured. These findings demonstrate the potential of each particle size to cause significant damage to the immune system. Moreover, because ZnO NPs inhibit the Na, K-F-ATPase activity at all concentrations and increase serum Ca2+ and Cl- levels especially in gill, these particles are osmoregulatory and toxicant for tilapia fish. As a summary, both sizes of the particles have led to organ damage, osmoregulatory changes and immune disorder in tilapia fish. (C) 2015 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Foundation [2014/205]
dc.description.sponsorshipThis study was supported by the Canakkale Onsekiz Mart University Scientific Foundation (Project 2014/205).
dc.identifier.doi10.1016/j.chemosphere.2015.09.024
dc.identifier.endpage582
dc.identifier.issn0045-6535
dc.identifier.issn1879-1298
dc.identifier.pmid26398925
dc.identifier.scopus2-s2.0-84953790306
dc.identifier.scopusqualityQ1
dc.identifier.startpage571
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2015.09.024
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27283
dc.identifier.volume144
dc.identifier.wosWOS:000367774400074
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofChemosphere
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectZnO nanoparticles
dc.subjectOrgan pathologies
dc.subjectOsmoregulatory responses
dc.subjectImmunological parameters
dc.subjectOreochromis niloticus
dc.titleA comparative toxicity study between small and large size zinc oxide nanoparticles in tilapia (Oreochromis niloticus): Organ pathologies, osmoregulatory responses and immunological parameters
dc.typeArticle

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