Evaluation of clinical outcomes and risk factors associated with mortality in patients with Stenotrophomonas maltophilia bloodstream infection: a multicenter study

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dc.contributor.authorGezer, Yakup
dc.contributor.authorTaysi, Muhammet Ridvan
dc.contributor.authorTarakci, Arzu
dc.contributor.authorGokce, Ozlem
dc.contributor.authorDanaci, Gamze
dc.contributor.authorToplu, Sibel Altunisik
dc.contributor.authorKarakas, Ezgi Erdal
dc.date.accessioned2025-01-27T20:28:59Z
dc.date.available2025-01-27T20:28:59Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackgroundStenotrophomonas maltophilia, a pathogen that colonizes medical equipment and causes nosocomial infections due to its ability to form biofilms, has high mortality rates. This study investigated the risk factors related to mortality in patients who were diagnosed with S. maltophilia bacteremia.MethodsIt is a multi-center, retrospective ad observational cohort study. The demographic characteristics, clinical findings, microbiological data, and risk factors for patients were obtained from the medical records of patients at ten different hospitals between January 1, 2018, and June 30, 2023.ResultsThe study included a total of 321 patients. The observed thirty-day mortality rate was 46.1%. A central venous catheter (CVC) was present in 276 patients (86%), and in 66 of these patients (23.9%) the CVC was removed. While only 18 patients (5.6%) received appropriate empirical antibiotics, 242 (75.4%) patients received appropriate antibiotics according to antimicrobial susceptibility test (AST) results and treatment revisions. Multivariate analysis revealed that advanced age (hazard ratio [HR] = 1.02; 95% confidence interval [CI]: 1.00- 1.03), appropriate antibiotic treatment (HR = 0.35; 95% CI: 0.23-0.52), and removal of central venous catheters (HR = 0.31; 95% CI: 0.16-0.60) were significantly related to reduced mortality.ConclusionsS. maltophilia is a significant pathogen, and to reduce its high mortality rate, removal of the CVC and switching to appropriate antibiotics should be performed as soon as possible.
dc.identifier.doi10.1186/s12879-024-10293-4
dc.identifier.issn1471-2334
dc.identifier.issue1
dc.identifier.pmid39639202
dc.identifier.scopus2-s2.0-85211095939
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12879-024-10293-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22757
dc.identifier.volume24
dc.identifier.wosWOS:001371831900003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofBmc Infectious Diseases
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAppropriate antibiotic
dc.subjectCentral venous catheter
dc.subjectMortality
dc.subjectRisk factors
dc.subjectStenotrophomonas maltophilia
dc.titleEvaluation of clinical outcomes and risk factors associated with mortality in patients with Stenotrophomonas maltophilia bloodstream infection: a multicenter study
dc.typeArticle

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