Effects of therapeutic dose of ivermectin on plasma nitric oxide and total antioxidant capacity in rabbits

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dc.authoridAtakisi, Onur/0000-0003-1183-6076
dc.contributor.authorAtakisi, E.
dc.contributor.authorAtakisi, O.
dc.contributor.authorTopcu, B.
dc.contributor.authorUzun, M.
dc.date.accessioned2025-01-27T20:11:56Z
dc.date.available2025-01-27T20:11:56Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Ivermectin, an acaricide and anthielmintic drug of the family of avermectins may produce free radicals thus resulting cytotoxic effect on the parasite. Nitric oxide (NO) acts as free radicals and as host defense mechanisms. The antioxidant capacity (TAC) can be described by the analysis of single components in the defense systems against free radicals. It was aimed to study the effects of therapeutic doses of ivermectin on the plasma adenosine deaminase (ADA) and gamma glutamyl transpeptidase activities (GGT), total antioxidant capacity (TAC), nitric oxide (NO) and total protein, albumin, globulin levels in rabbits. Material and Methods: Twenty healthy New Zealand rabbits were allocated to 2 equal groups. Group I received 0.5 mg/kg and Group II received 1 mg/kg of ivermectin via subcutaneous injection. Blood samples were collected before the experiment, at 24 and 120 hours following the treatments. Results: Ivermectin at therapeutic doses increased plasma NO level at 24 h while decreased TAC at 120 h and did not alter other parameters. Conclusion: These findings may suggest that ivermectin is a safe antiparasitic drug for mammals but to less extent, it may have an effect on the oxidant/antioxidant balance.
dc.identifier.endpage429
dc.identifier.issn1128-3602
dc.identifier.issue6
dc.identifier.pmid20085123
dc.identifier.scopus2-s2.0-74949099545
dc.identifier.scopusqualityQ2
dc.identifier.startpage425
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20785
dc.identifier.volume13
dc.identifier.wosWOS:000272628700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectIvermectin
dc.subjectNitric oxide
dc.subjectTotal antioxidant capacity
dc.subjectAdenosine deaminase
dc.subjectRabbit
dc.titleEffects of therapeutic dose of ivermectin on plasma nitric oxide and total antioxidant capacity in rabbits
dc.typeArticle

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