Evaluation of liver perfusion in diabetic patients using 99mTc-sestamibi

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dc.authoridAsik, mehmet/0000-0002-0716-0221
dc.authoridUkinc, KUBILAY/0000-0002-4727-7432
dc.contributor.authorSen, Hacer
dc.contributor.authorTan, Yusuf Ziya
dc.contributor.authorBinnetoglu, Emine
dc.contributor.authorAsik, Mehmet
dc.contributor.authorGunes, Fahri
dc.contributor.authorErbag, Gokhan
dc.contributor.authorGazi, Emine
dc.date.accessioned2025-01-27T20:34:34Z
dc.date.available2025-01-27T20:34:34Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective The liver is an important organ for various aspects of glucose metabolism, including glucose uptake, storage, and synthesis. It is a major organ in the metabolic process with perfusion provided by both the portal vein and hepatic artery. In diabetic patients organ perfusion is reduced and this is linked to atherosclerosis, and as a result complications occur. In this study, we aimed to evaluate liver perfusion by scintigraphic methods in diabetic patients. Design and patients We retrospectively investigated 1,100 myocardial perfusion scintigraphies taken between January 2011 and December 2012 at Canakkale Onsekiz Mart University Medical Faculty Nuclear Medicine Department. A total of 66 patients who were diagnosed with diabetes mellitus and had myocardial perfusion scintigraphies were included in the study. The control subjects included 127 patients without diabetes mellitus who were chosen at random. Patients with chronic liver disease were not included in the study. The values from liver regions of interest (liver-ROI) rates and heart regions of interest (heart-ROI) rates were compared between the patients and controls. Results Patients were grouped according to the presence of diabetes. In the diabetes mellitus group, the liver-ROI average was lower (p = 0.66) than in the controls. In the control group, the average liver-ROI/heart-ROI ratios were higher than the ratio in the diabetes mellitus group (p = 0.019). Multivariate variance analysis showed that the diabetes mellitus liver-ROI/heart-ROI ratio was independent of other risk factors (p = 0.003; F: 9.6). Powered by Editorial Manager. and ProduXion Manager. from Aries Systems Corporation. Conclusions This study shows that liver perfusion in diabetic patients is reduced compared with those without diabetes. Prospective studies with larger patient groups are required.
dc.identifier.doi10.1007/s00508-014-0614-5
dc.identifier.endpage23
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue1-2
dc.identifier.pmid25234941
dc.identifier.scopus2-s2.0-84922004643
dc.identifier.scopusqualityQ1
dc.identifier.startpage19
dc.identifier.urihttps://doi.org/10.1007/s00508-014-0614-5
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23358
dc.identifier.volume127
dc.identifier.wosWOS:000348787900005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDiabetes mellitus
dc.subjectLiver perfusion
dc.subjectTechnetium-99m-2-methoxy-isobutyl-isonitrite
dc.subjectLiver scintigraphy
dc.titleEvaluation of liver perfusion in diabetic patients using 99mTc-sestamibi
dc.title.alternativeErhebung der Leberperfusion mittels 99mTc-Sestamibi bei Patienten mit Diabetes mellitus
dc.typeArticle

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