Circulating cell free DNA and miRNA Amount in Congenital Hearing Loss
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Our aim is to detect the amount of miRNA and free DNA in the peripheral blood of young people with congenital hearing loss and compare this with control group.Materials and Methods: In our study, 16 patients who have congenital hearing lossand go to the private school for deaf children and 16 healthy individuals were select-ed in the same age group. 5 cc blood was taken from peripheral vessels of each individual. We compared the circulating cell-free DNA and miRNA amount with the results of the control group.Results: The ccfDNA amount of the patients with hearing loss was lower than thecontrol group and It was statistically significant. On the contrary, we found the high-er amount of ccfmiRNA in plasma samples of the patients with hearing loss. The statistical analysis showed that ccfmiRNA amount in congenital loss is consistently sig-nificantly higher than the control group.Conclusion: The miRNA and freeDNA can be used early in the diagnosis of congenital hearing loss.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp, Odyoloji ve Konuşma-Dil Patolojisi
Kaynak
Acta Medica
WoS Q Değeri
Scopus Q Değeri
Cilt
49
Sayı
3
