Mitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study

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dc.authoridDOLCINI, JACOPO/0000-0001-5250-1833
dc.authoridSanchez-Guerra, Marco/0000-0002-8354-1157
dc.contributor.authorDolcini, Jacopo
dc.contributor.authorWu, Haotian
dc.contributor.authorNwanaji-Enwerem, Jamaji C.
dc.contributor.authorKiomourtozlogu, Marianthi-Anna
dc.contributor.authorCayir, Akin
dc.contributor.authorSanchez-Guerra, Marco
dc.contributor.authorVokonas, Pantel
dc.date.accessioned2025-01-27T20:29:09Z
dc.date.available2025-01-27T20:29:09Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPopulation aging is a looming global health challenge. New biological aging metrics based on DNA methylation levels have been developed in addition to traditional aging biomarkers. The prospective relationships of aging biomarkers with mitochondrial changes are still not well understood. Here, we examined the prospective associations of mitochondrial copy number (mtDNAcn) with several aging biomarkers - DNAm-Age, DNAm-PhenoAge, DNAm-GrimAge, and leukocyte telomere length. We analyzed 812 individuals from Veteran Affairs Normative Aging Study (NAS) with available blood samples from 1999-2013. Whole blood mtDNAcn and relative leukocyte telomere length were measured via qPCR. DNA methylation was assessed and used to calculate DNAm-Age, DNAm-GrimAge, and DNAm-PhenoAge. Linear mixed models were used to quantify the associations of mtDNAcn with DNAm-Age, DNAm-GrimAge, DNAm-PhenoAge, and leukocyte telomere length. In multivariable cross-sectional analyses, mtDNAcn is negatively associated with DNAm-Age PhenoAge and DNAm-PhenoAge. In contrast, mtDNAcn is associated with prospective measures of higher DNAm-PhenoAge and shorter leukocyte telomere length. Our study shows that higher mtDNAcn is associated with prospective measures of greater DNAm-PhenoAge and shorter leukocyte telomere length independent of chronological age. This indicates a role for mitochondrial in aging-related disease and mortality, but not the departure of biological age from chronological age.
dc.description.sponsorshipNational Institutes of Health [R01ES025225, R01ES021733, R01ES027747, P30ES009089]; Cooperative Studies Program/Epidemiology Research and Information Center of the U.S. Department of Veterans Affairs
dc.description.sponsorshipThis work was supported by National Institutes of Health (R01ES025225, R01ES021733, R01ES027747, P30ES009089); The VA Normative Aging Study is supported by the Cooperative Studies Program/Epidemiology Research and Information Center of the U.S. Department of Veterans Affairs and is a component of the Massachusetts Veterans Epidemiology Research and Information Center, Boston, Massachusetts.
dc.identifier.doi10.18632/aging.102722
dc.identifier.endpage2083
dc.identifier.issn1945-4589
dc.identifier.issue3
dc.identifier.pmid32009007
dc.identifier.scopus2-s2.0-85080841244
dc.identifier.scopusqualityQ1
dc.identifier.startpage2070
dc.identifier.urihttps://doi.org/10.18632/aging.102722
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22847
dc.identifier.volume12
dc.identifier.wosWOS:000514798700007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherImpact Journals Llc
dc.relation.ispartofAging-Us
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectepigenetic
dc.subjectaging
dc.subjectmitochondria
dc.subjecttelomere length
dc.subjectpublic health
dc.titleMitochondria and aging in older individuals: an analysis of DNA methylation age metrics, leukocyte telomere length, and mitochondrial DNA copy number in the VA normative aging study
dc.typeArticle

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