Increased Platelet Distribution Width Is Associated With Severity of Coronary Artery Disease in Patients With Acute Coronary Syndrome

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dc.authoridTENEKECIOGLU, ERHAN/0000-0003-4376-2833
dc.contributor.authorBekler, Adem
dc.contributor.authorOzkan, Muhammed Turgut Alper
dc.contributor.authorTenekecioglu, Erhan
dc.contributor.authorGazi, Emine
dc.contributor.authorYener, Ali Umit
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorAltun, Burak
dc.date.accessioned2025-01-27T20:27:37Z
dc.date.available2025-01-27T20:27:37Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPlatelet activation plays a pivotal role in acute coronary syndrome (ACS). We investigated the relationship between platelet distribution width (PDW) and severity of coronary artery disease (CAD) in patients with ACS. A total of 502 patients with ACS were enrolled. High (n = 151) and low PDW (n = 351) groups were defined as patients having values in the third tertile (>17%) and lower 2 tertiles (17%). There were significantly higher Gensini score (44 [10-168] vs 36 [2-132], P < .001), and neutrophil-lymphocyte ratio (3.1 [0.8-12.4] vs 2.5 [0.3-13], P = .012) and baseline platelet counts were significantly lower (220 [61-623] vs 233 [79-644] 10(3)/mm(3), P = .022) in the high PDW group. The variables PDW >17%, diabetes mellitus, and myocardial infarction were found to be associated with high Gensini score (odds ratio [OR]: 1.91, 95% confidence interval [CI]: 1.27-2.88, P = .002; OR: 2.85, 95%CI: 1.91-4.25, P < .001; OR: 2.67, 95% CI:1.74-4.1, P < .001, respectively). An increased PDW (>17%) is associated with severity of CAD in patients with ACS.
dc.identifier.doi10.1177/0003319714545779
dc.identifier.endpage643
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue7
dc.identifier.pmid25112777
dc.identifier.scopus2-s2.0-84937903308
dc.identifier.scopusqualityQ2
dc.identifier.startpage638
dc.identifier.urihttps://doi.org/10.1177/0003319714545779
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22735
dc.identifier.volume66
dc.identifier.wosWOS:000358577600008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofAngiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectacute coronary syndrome
dc.subjectGensini score
dc.subjectplatelet distribution width
dc.titleIncreased Platelet Distribution Width Is Associated With Severity of Coronary Artery Disease in Patients With Acute Coronary Syndrome
dc.typeArticle

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