Caffeic Acid Phenethyl Ester Prevents Detrimental Effects of Remote Ischemia-Reperfusion Injury on Healing of Colonic Anastomoses

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dc.authoridYenisey, Cigdem/0000-0001-7693-641X
dc.authoridTeke, Zafer/0000-0001-8869-6476
dc.contributor.authorTeke, Zafer
dc.contributor.authorBostanci, Erdal Birol
dc.contributor.authorYenisey, Cigdem
dc.contributor.authorKelten, Esra Canan
dc.contributor.authorSacar, Mustafa
dc.contributor.authorSimsek, Nilufer Genc
dc.contributor.authorDuzcan, Suleyman Ender
dc.date.accessioned2025-01-27T20:41:02Z
dc.date.available2025-01-27T20:41:02Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: We aimed to investigate whether caffeic acid phenethyl ester (CAPE) prevents detrimental systemic effects of intestinal ischemia-reperfusion (IR) injury on colonic anastomotic wound healing. Methods: This experimental study was conducted on 48 male Wistar albino rats. The rats were randomly allocated into four groups and a left colonic anastomosis was performed in all rats: (i) sham-operated group (n = 12), laparatomy without intestinal IR injury; (ii) sham + CAPE group (n = 12), identical to Group 1 except for CAPE treatment (10 mu mol/kg, intravenously); (iii) intestinal IR group (n = 12), 60 min of superior mesenteric ischemia followed by reperfusion; and (iv) IR + CAPE-treated group (n = 12) (10 mu mol/kg, intravenously, 30 min before the construction of colonic anastomosis). On the postoperative day 7, the rats were subjected to relaparotomy for in vivo measurement of the colonic anastomotic bursting pressure. A colonic segment including the anastomotic site was resected for histopathological evaluation and biochemical analyses. The plasma proinflammatory cytokine levels were measured. Body weight changes were examined. Results: CAPE treatment significantly increased colonic anastomotic bursting pressures, and colonic anastomotic tissue hydroxyproline contents and antioxidant parameters (p < .05), and significantly decreased oxidative stress markers in colonic anastomotic tissues and plasma proinflammatory cytokine levels (p < .05). Histopathological scores were significantly better due to CAPE administration (p < .05). Conclusions: This study clearly showed that CAPE treatment prevented the delaying effects of remote IR injury on colonic anastomotic wound healing. Further clinical studies are required to determine whether CAPE has a useful role in the enhancement of gastrointestinal anastomotic wound healing during particular surgeries in which IR-induced organ injury occurs.
dc.identifier.doi10.3109/08941939.2012.687434
dc.identifier.endpage29
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue1
dc.identifier.pmid22646141
dc.identifier.scopus2-s2.0-84873675895
dc.identifier.scopusqualityQ1
dc.identifier.startpage16
dc.identifier.urihttps://doi.org/10.3109/08941939.2012.687434
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23980
dc.identifier.volume26
dc.identifier.wosWOS:000314650400004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcaffeic acid phenethyl ester
dc.subjectischemia-reperfusion
dc.subjectcolonic anastomosis
dc.subjectwound healing
dc.subjectbursting pressures
dc.subjecthydroxyproline
dc.subjectmyeloperoxidase
dc.subjectmalondialdehyde
dc.subjectxanthine oxidase
dc.subjectnitric oxide
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectglutathione reductase
dc.subjectcatalase
dc.titleCaffeic Acid Phenethyl Ester Prevents Detrimental Effects of Remote Ischemia-Reperfusion Injury on Healing of Colonic Anastomoses
dc.typeArticle

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