Hypothyroid Graves' disease complicated with elephantiasis nostras verrucosa (ENV): a case report and review of the literature

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dc.authoridUkinc, KUBILAY/0000-0002-4727-7432
dc.contributor.authorUkinc, Kubilay
dc.contributor.authorBayraktar, Miyase
dc.contributor.authorGedik, Arzu
dc.date.accessioned2025-01-27T20:52:31Z
dc.date.available2025-01-27T20:52:31Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThyroid dermopathy is not a frequent feature of hyperthyroid Graves' disease, being present in less than 5% of the patients. Graves' disease has been shown to exist in euthyroid or hypothyroid forms in untreated patients. Here, we describe a case of hypothyroid Graves' disease with elephantiasis nostras verrucosa (ENV), which is an extreme form of thyroid dermopathy (TD). A 58-year-old female patient was admitted to the emergency department with somnolence, hypothermia, and bradycardia. Her mental status gradually worsened, resulting in a deep coma. She was intubated and followed in the intensive care unit, as she needed mechanical ventilatory assistance due to respiratory failure. She also had bilateral non-pitting edema, a cobblestone-like appearance, and hyperkeratotic greenish-brown-colored lesions in the pretibial and dorsal regions of the feet that were compatible with ENV. Hypothyroid Graves' disease is a very rare condition among autoimmune thyroid disorders, and ENV is an extremely rare form of TD. Here, we present a patient with hypothyroid Graves' disease and ENV.
dc.identifier.doi10.1007/s12020-009-9200-4
dc.identifier.endpage9
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue1
dc.identifier.pmid19390996
dc.identifier.scopus2-s2.0-70349568488
dc.identifier.scopusqualityQ2
dc.identifier.startpage6
dc.identifier.urihttps://doi.org/10.1007/s12020-009-9200-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25787
dc.identifier.volume36
dc.identifier.wosWOS:000267781000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHypothyroid Graves'
dc.subjectAutoimmune thyroid disease
dc.subjectThyroid dermopathy
dc.subjectElephantiasis nostras verrucosa
dc.titleHypothyroid Graves' disease complicated with elephantiasis nostras verrucosa (ENV): a case report and review of the literature
dc.typeReview Article

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