Lactoferrin: A Promising Therapeutic Molecule against Human Papillomavirus

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dc.authoridRaposo, Antonio/0000-0002-5286-2249
dc.authoridKalkan, Arda Erkan/0009-0003-6141-862X
dc.authoridLombardo, Mauro/0000-0001-7509-5487
dc.authoridde Brito Alves, Jose Luiz/0000-0003-4696-3809
dc.authoridWitkowska, Anna/0000-0002-0092-3409
dc.authoridKARAV, SERCAN/0000-0003-4056-1673
dc.contributor.authorKaplan, Merve
dc.contributor.authorBaktiroglu, Merve
dc.contributor.authorKalkan, Arda Erkan
dc.contributor.authorCanbolat, Ahmet Alperen
dc.contributor.authorLombardo, Mauro
dc.contributor.authorRaposo, Antonio
dc.contributor.authorAlves, Jose Luiz de Brito
dc.date.accessioned2025-01-27T20:41:21Z
dc.date.available2025-01-27T20:41:21Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractLactoferrin is a multifunctional glycoprotein naturally found in mammalian secretions, predominantly in colostrum and milk. As a key component of dairy foods, lactoferrin enhances viral protection and boosts human health, owing to its fundamental properties including antiviral, anti-inflammatory, and immune-modulatory effects. Importantly, the antiviral effect of lactoferrin has been shown against a range of viruses causing serious infections and threatening human health. One of the viruses that lactoferrin exerts significant antiviral effects on is the human papillomavirus (HPV), which is the most prevalent transmitted infection affecting a myriad of people around the world. Lactoferrin has a high potential to inhibit HPV via different mechanisms, including direct binding to viral envelope proteins or their cell receptors, thereby hindering viral entry and immune stimulation by triggering the release of some immune-related molecules through the body, such as lymphocytes. Along with HPV, lactoferrin also can inhibit a range of viruses including coronaviruses and hepatitis viruses in the same manner. Here, we overview the current knowledge of lactoferrin and its effects on HPV and other viral infections.
dc.description.sponsorshipThis research received no external funding.
dc.identifier.doi10.3390/nu16183073
dc.identifier.issn2072-6643
dc.identifier.issue18
dc.identifier.pmid39339673
dc.identifier.scopus2-s2.0-85205255138
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/nu16183073
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24114
dc.identifier.volume16
dc.identifier.wosWOS:001322920700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofNutrients
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectlactoferrin
dc.subjectnatural compound
dc.subjectdairy foods
dc.subjectmilk
dc.subjectantiviral
dc.subjecthuman papillomavirus
dc.subjectHPV
dc.titleLactoferrin: A Promising Therapeutic Molecule against Human Papillomavirus
dc.typeReview Article

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