Treatment of hemorrhagic gastritis by Ankaferd blood stopper versus Omeprazole: experimental randomized rat models

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dc.contributor.authorBatgi, Hikmetullah
dc.contributor.authorAkbal, Erdem
dc.contributor.authorKocak, Erdem
dc.contributor.authorAkyurek, Omer
dc.contributor.authorKoklu, Seyfettin
dc.contributor.authorDonmez, Melahat
dc.contributor.authorGunes, Fahri
dc.date.accessioned2025-01-27T21:02:11Z
dc.date.available2025-01-27T21:02:11Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAnkaferd blood stopper (ABS) is a herbal extract that enhances mucosal healing. It has therapeutic potential in the management of external hemorrhage and controlling gastrointestinal bleeding associated with various benign lesions refractory to conventional antihemorrhagic measures. The aim of this experimental study was to assess the effects of ABS on hemorrhagic lesions and compare them with omeprazole. The study was conducted on 30 rats. Rats were divided into five groups: group A (only indomethacin), group B (ABS administration 60 min before indomethacin-induced injury), group C (ABS administration 30 min after indomethacin-induced injury), group D (omeprazole administration 60 min before indomethacinaEuroinduced injury), group E (omeprazole administration 30 min after indomethacinaEuroinduced injury). Gastric mucosal lesions were produced by indomethacin in all three groups. The effect was studied morphologically 6 h after oral administration of the drug. Subsequently, affected tissue was examined histologically. Based on the number and the total size of hemorrhagic lesions, the hemorrhagic lesion scores were significantly better in Group C compared to other groups (p < 0.05). The hemorrhagic lesion score of Group B was significantly better than Group D and Group A (p < 0.05). Omeprazole groups (Group D, Group E) did not show significant improvement as indicated by macroscopic scores. There was no significant difference between the groups with respect to microscopic scores. These results indicate that ABS has a potent inhibitory action on indomethacin-induced gastric bleeding and mucosal lesions and it is useful in the treatment of acute gastric mucosal lesions.
dc.identifier.doi10.1007/s00508-015-0762-2
dc.identifier.endpageS565
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.pmid25860852
dc.identifier.scopus2-s2.0-85006990599
dc.identifier.scopusqualityQ1
dc.identifier.startpageS559
dc.identifier.urihttps://doi.org/10.1007/s00508-015-0762-2
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27304
dc.identifier.volume128
dc.identifier.wosWOS:000391829500002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAnkaferd blood stopper
dc.subjectHemorrhagic gastritis
dc.subjectOmeprazole
dc.titleTreatment of hemorrhagic gastritis by Ankaferd blood stopper versus Omeprazole: experimental randomized rat models
dc.typeArticle

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