Mechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health

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dc.contributor.authorPekdemir, Burcu
dc.contributor.authorRaposo, Antonio
dc.contributor.authorSaraiva, Ariana
dc.contributor.authorLima, Maria Joao
dc.contributor.authorAlsharari, Zayed D.
dc.contributor.authorBinmowyna, Mona N.
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-01-27T20:34:40Z
dc.date.available2025-01-27T20:34:40Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe brain contains many interconnected and complex cellular and molecular mechanisms. Injury to the brain causes permanent dysfunctions in these mechanisms. So, it continues to be an area where surgical intervention cannot be performed except for the removal of tumors and the repair of some aneurysms. Some agents that can cross the blood-brain barrier and reach neurons show neuroprotective effects in the brain due to their anti-apoptotic, anti-inflammatory and antioxidant properties. In particular, some agents act by reducing or modulating the accumulation of protein aggregates in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and prion disease) caused by protein accumulation. Substrate accumulation causes increased oxidative stress and stimulates the brain's immune cells, microglia, and astrocytes, to secrete proinflammatory cytokines. Long-term or chronic neuroinflammatory response triggers apoptosis. Brain damage is observed with neuronal apoptosis and brain functions are impaired. This situation negatively affects processes such as motor movements, memory, perception, and learning. Neuroprotective agents prevent apoptosis by modulating molecules that play a role in apoptosis. In addition, they can improve impaired brain functions by supporting neuroplasticity and neurogenesis. Due to the important roles that these agents play in central nervous system damage or neurodegenerative diseases, it is important to elucidate many mechanisms. This review provides an overview of the mechanisms of flavonoids, which constitute a large part of the agents with neuroprotective effects, as well as vitamins, neurotransmitters, hormones, amino acids, and their derivatives. It is thought that understanding these mechanisms will enable the development of new therapeutic agents and different treatment strategies.
dc.identifier.doi10.3390/nu16244368
dc.identifier.issn2072-6643
dc.identifier.issue24
dc.identifier.pmid39770989
dc.identifier.scopus2-s2.0-85213456493
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/nu16244368
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23412
dc.identifier.volume16
dc.identifier.wosWOS:001384496300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofNutrients
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectanti-inflammatory
dc.subjectantioxidant
dc.subjectneurodegenerative
dc.subjectneuroplasticity
dc.subjectneuroprotection
dc.titleMechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health
dc.typeReview Article

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