Rod-like L-Aspartic acid-Cu(II) metal organic frameworks; Synthesis, characterization and biomedical properties
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivs 3.0 United States
Attribution-NonCommercial-NoDerivs 3.0 United States
Özet
L-aspartic acid (L-AA) based MOFs were prepared from acetate, chloride, nitrate, and sulfate salts of Cu(II) ions as
L-AA-Cu(II)-A,-C,-N,-S, respectively with 96.7 2.4, 89.8 3.1, 92.1 1.5, 74.6 5.2 m2/g, surface areas. L-AA-
Cu(II)-MOFs in the same order induced 0.43 0.25%, 0.94 0.24%, 0.91 0.40%, 1.18 0.10% hemolysis, all
being <2%, and blood clotting indices of ~90% and can be considered nonhemolytic and non-coagulative at 1
μg/mL concentration. L-AA-Cu(II)-A MOFs exhibited 86.3 0.2, and 92.4 0.6% α-Glucosidase inhibitory ac-
tivities at 1.0 and 10.0 μg/mL concentrations, respectively. Moreover, L-AA-Cu(II)-S MOFs had effective anti-
microbial activities against E. coli (ATCC-8739), and S. aureus (ATCC-6538) with MIC values of 0.63 mg/mL and
1.25 mg/mL for C. albicans (ATCC-10231). L-AA-Cu(II) MOFs synthesized herein with hemocompatible, antimi-
crobial and antidiabetic properties prompt interesting possibilities for both industrial and biomedical
applications
Açıklama
Anahtar Kelimeler
Antidiabetic, Antimicrobial, Bio-MOF, Blood compatible, L-aspartic acid, Porous Coordination network
Kaynak
Current Research in Green and Sustainable Chemistry
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
Künye
Gizer, G., Sahiner, M., Yildirim, Y., Demirci, S., Can, M., & Sahiner, N. (2021). Rod-like L-aspartic acid-cu(II) metal organic frameworks; synthesis, characterization and biomedical properties. Current Research in Green and Sustainable Chemistry, 4 doi:10.1016/j.crgsc.2021.100110
