Experimental Esophagitis Model Preventing Tracheal Aspiration

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dc.contributor.authorKiraz, Hasan A.
dc.contributor.authorErbas, Mesut
dc.contributor.authorKucuk, Adem
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorErdem, Havva
dc.contributor.authorSahin, Hasan
dc.contributor.authorToman, Huseyin
dc.date.accessioned2025-01-27T20:23:00Z
dc.date.available2025-01-27T20:23:00Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground. Corrosive esophagitis injuries are a serious clinical problem with many agents used for diagnosis and treatment. Experimental esophagus burn models use a method described mainly in studies by Gehanno and Guedon, and modified by Liu and Richardson. Objectives. The aim of this study was to describe a new esophagitis model that prevents tracheal aspiration. Material and Methods. In this study we used 16 Wistar albino rats weighing between 220-240 g. The experimental animals were randomly divided into two groups: the model group (group M, n: 8) and control group (group C, n: 8). The necessary anesthesia was administered. Passing through a median laparotomy incision, the abdomen was entered and in group M and C the esophagus was freed and held by a suture at the gastroesophageal junction. After this procedure, about 1 cm proximal to the gastroesophageal junction, the esophagus was suspended by a suture. The esophagus segment between the two sutures was exposed to 0.1 mL 10% NaOH in group M and 0.1 mL saline in group C for 20 s. Ten days later all experimental animals were sacrificed and their esophagus removed. After dying with hematoxylin and eosine trichrome, the histopathological evaluation results for the rats in all groups were investigated with a light microscope. Results. Histopathological examination indicated submucosal collagen increase, damage to muscularis mucosa and tunica muscularis and collagen deposition. In the model group, the rats had high neutrophils and tissue damage accompanied by necrosis. In the control group, the rats had minimal or no tissue damage and fibrosis was not observed. Conclusions. Our procedure is relatively less invasive and easy to apply with corrosive esophagitis only in the required region, and at the same time treatment medications can be easily administered.
dc.identifier.doi10.17219/acem/22364
dc.identifier.endpage641
dc.identifier.issn1899-5276
dc.identifier.issn2451-2680
dc.identifier.issue4
dc.identifier.pmid26469108
dc.identifier.scopus2-s2.0-84945136585
dc.identifier.scopusqualityQ1
dc.identifier.startpage637
dc.identifier.urihttps://doi.org/10.17219/acem/22364
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22094
dc.identifier.volume24
dc.identifier.wosWOS:000360287300011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWroclaw Medical Univ
dc.relation.ispartofAdvances in Clinical and Experimental Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectexperimental model
dc.subjectcorrosive esophagitis
dc.subjectNaOH
dc.subjecttracheal aspiration
dc.titleExperimental Esophagitis Model Preventing Tracheal Aspiration
dc.typeArticle

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