Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

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dc.authoridShinwari, Zabta/0000-0002-0368-7966
dc.authoridOzleyen, Adem/0000-0003-0195-3383
dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridTumer, Tugba/0000-0002-1740-4867
dc.authoridKhan, Tariq/0000-0002-9194-9240
dc.authoridGyawali, Rabin/0000-0003-1782-1772
dc.authoridMartorell, Miquel/0000-0003-3183-7623
dc.contributor.authorSalehi, Bahare
dc.contributor.authorZakaria, Zainul Amiruddin
dc.contributor.authorGyawali, Rabin
dc.contributor.authorIbrahim, Salam A.
dc.contributor.authorRajkovic, Jovana
dc.contributor.authorShinwari, Zabta Khan
dc.contributor.authorKhan, Tariq
dc.date.accessioned2025-01-27T20:31:51Z
dc.date.available2025-01-27T20:31:51Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPiper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.
dc.description.sponsorshipCONICYT PIA/APOYO CCTE [AFB170007]
dc.description.sponsorshipContributions from L.M.F. and W.N.S in this work were performed as part of the activities of the Research Network Natural Products against Neglected Diseases (ResNetNPND), (http://www.resnetnpnd.org/Start/. Also, this work was supported by CONICYT PIA/APOYO CCTE AFB170007.
dc.identifier.doi10.3390/molecules24071364
dc.identifier.issn1420-3049
dc.identifier.issue7
dc.identifier.pmid30959974
dc.identifier.scopus2-s2.0-85064069885
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules24071364
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23288
dc.identifier.volume24
dc.identifier.wosWOS:000464955400004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectpepper
dc.subjectessential oil
dc.subjectantimicrobial
dc.subjecttraditional medicine
dc.subjectanticancer
dc.subjectanti-inflammatory
dc.titlePiper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications
dc.typeReview Article

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