Diagnostic and Prognostic Roles of Procalcitonin and Other Tools in Community-Acquired Pneumonia: A Narrative Review

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dc.authorid0000-0002-3427-5649en_US
dc.authorscopusid57213614084en_US
dc.authorwosid-en_US
dc.contributor.authorÖzbay, Sedat
dc.contributor.authorAyan, Mustafa
dc.contributor.authorÖzsoy, Orhan
dc.contributor.authorAkman, Canan
dc.contributor.authorKarcıoğlu, Özgür
dc.date.accessioned2024-01-22T07:39:12Z
dc.date.available2024-01-22T07:39:12Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractCommunity-acquired pneumonia (CAP) is among the most common causes of death and one of the leading healthcare concerns worldwide. It can evolve into sepsis and septic shock, which have a high mortality rate, especially in critical patients and comorbidities. The definitions of sepsis were revised in the last decade as “life-threatening organ dysfunction caused by a dysregulated host response to infection”. Procalcitonin (PCT), C-reactive protein (CRP), and complete blood count, including white blood cells, are among the most commonly analyzed sepsis-specific biomarkers also used in pneumonia in a broad range of studies. It appears to be a reliable diagnostic tool to expedite care of these patients with severe infections in the acute setting. PCT was found to be superior to most other acute phase reactants and indicators, including CRP as a predictor of pneumonia, bacteremia, sepsis, and poor outcome, although conflicting results exist. In addition, PCT use is beneficial to judge timing for the cessation of antibiotic treatment in most severe infectious states. The clinicians should be aware of strengths and weaknesses of known and potential biomarkers in expedient recognition and management of severe infections. This manuscript is intended to present an overview of the definitions, complications, and outcomes of CAP and sepsis in adults, with special regard to PCT and other important markers.en_US
dc.identifier.citationÖzbay, S., Ayan, M., Özsoy, O., Akman, C., & Karcıoğlu, O. (2023). Diagnostic and Prognostic Roles of Procalcitonin and Other Tools in Community-Acquired Pneumonia: A Narrative Review. Diagnostics, 13(11). https://doi.org/10.3390/diagnostics13111869en_US
dc.identifier.doi10.3390/diagnostics13111869
dc.identifier.issn2075-4418
dc.identifier.issue11en_US
dc.identifier.pmid37296721
dc.identifier.scopus2-s2.0-85161728490
dc.identifier.urihttps://doi.org/10.3390/diagnostics13111869
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5281
dc.identifier.volume13en_US
dc.identifier.wosWOS:001005078800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkman, Canan
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectAntibiotic stewardshipen_US
dc.subjectBacteremiaen_US
dc.subjectBiomarkeren_US
dc.subjectDiagnosisen_US
dc.subjectOutcomeen_US
dc.subjectPneumoniaen_US
dc.subjectProcalcitoninen_US
dc.subjectSepsisen_US
dc.titleDiagnostic and Prognostic Roles of Procalcitonin and Other Tools in Community-Acquired Pneumonia: A Narrative Review
dc.typeReview Article

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