Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

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dc.authoridSharopov, Farukh/0000-0003-0378-8887
dc.authoridMartorell, Miquel/0000-0003-3183-7623
dc.authoridCalina, Daniela/0000-0002-1523-9116
dc.authoridCruz-Martins, Natalia/0000-0002-5934-5201
dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridDocea, Anca Oana/0000-0002-8162-5955
dc.authoridDias, Daniel/0000-0003-0129-3178
dc.contributor.authorSharifi-Rad, Mehdi
dc.contributor.authorLankatillake, Chintha
dc.contributor.authorDias, Daniel A.
dc.contributor.authorDocea, Anca Oana
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorLobine, Devina
dc.contributor.authorChazot, Paul L.
dc.date.accessioned2025-01-27T20:12:15Z
dc.date.available2025-01-27T20:12:15Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAmong the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT-Portugal) [UID/BIM/04293/2013]; NORTE2020-Programa Operacional Regional do Norte [NORTE-01-0145-FEDER-000012]; CONICYT PIA/APOYO CCTE [AFB170007]
dc.description.sponsorshipN. Martins would like to thank the Portuguese Foundation for Science and Technology (FCT-Portugal) for the Strategic project ref. UID/BIM/04293/2013 and NORTE2020-Programa Operacional Regional do Norte (NORTE-01-0145-FEDER-000012). This work also was supported by CONICYT PIA/APOYO CCTE AFB170007. Thanks also to Janet Chazot for Editorial support.
dc.identifier.doi10.3390/jcm9041061
dc.identifier.issn2077-0383
dc.identifier.issue4
dc.identifier.pmid32276438
dc.identifier.scopus2-s2.0-85088468256
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm9041061
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20893
dc.identifier.volume9
dc.identifier.wosWOS:000531821000168
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectneurodegenerative disorders
dc.subjectAlzheimer's disease
dc.subjectdementias
dc.subjectParkinson's disease
dc.subjectnatural compounds
dc.subjectplants secondary metabolites
dc.subjectpharmacological activities
dc.titleImpact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics
dc.typeReview Article

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