Correlation between Bethatrophin and 25(OH)D Concentrations in a Group of Subjects With Normal and Impaired Glucose Metabolism

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dc.contributor.authorTurkon, H.
dc.contributor.authorYalcin, H.
dc.contributor.authorToprak, B.
dc.contributor.authorDemirpence, M.
dc.contributor.authorYasar, H. Y.
dc.contributor.authorColak, A.
dc.date.accessioned2025-01-27T20:16:31Z
dc.date.available2025-01-27T20:16:31Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim Inducing beta cell replication is a potential therapeutic approach for the treatment of diabetes mellitus. Recently betatrophin was suggested as a novel stimulator of beta cell proliferation in mice but its role in humans remains to be established. We aimed to investigate betatrophin concentration and its association with metabolic parameters in a group of individuals with normal glucose tolerance, pre-diabetes and diabetes mellitus who had not been previously treated. Methods A total of 72 subjects were recruited for this cross sectional study: 23 subjects with normal glucose tolerance (NGT), 22 subjects with prediabetes, and 27 subjects with diabetes mellitus (DM). Circulating betatrophin concentration, 75 g oral glucose tolerance test, fasting insulin, glycosylated hemoglobin, 25hydroxy vitamin D and HOMA IR were measured. Results The difference in betatrophin values did not reach statistical significance between the 3 groups [NGT: 206 (176-297) pg/mL, Prediabetes: 232 (181-254) pg/mL, DM: 245 (205-526) pg/mL, p = 0.078]. Betatrophin was negatively significantly correlated with BMI and positively significantly correlated with 25(OH) vitD (p = 0.043 and p = 0.001 respectively). Multivariate linear regression showed that 25(OH) vitD (beta = 0.440 p = 0.001) and fasting glucose (beta = 0.003 p = 0.038) were variables associated with betatrophin concentration (R2 = 0.251). Conclusions In a group of subjects ranging from those with normal glucose tolerance to newly diagnosed diabetes, we found that 25(OH) D and fasting glucose were factors associated with serum betatrophin concentration.
dc.identifier.doi10.1055/s-0042-101791
dc.identifier.endpage150
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue3
dc.identifier.pmid26910534
dc.identifier.scopus2-s2.0-84959216869
dc.identifier.scopusqualityQ2
dc.identifier.startpage147
dc.identifier.urihttps://doi.org/10.1055/s-0042-101791
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21271
dc.identifier.volume125
dc.identifier.wosWOS:000395766100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofExperimental and Clinical Endocrinology & Diabetes
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbetatrophin
dc.subjectOGTT
dc.subjectvitamin D
dc.titleCorrelation between Bethatrophin and 25(OH)D Concentrations in a Group of Subjects With Normal and Impaired Glucose Metabolism
dc.typeArticle

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