Oxybutynin effects on Staphylococcus epidermidis biofilm production

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dc.contributor.authorGedik, Abdullah
dc.contributor.authorErsay, Ahmet
dc.contributor.authorAtmaca, Selahattin
dc.contributor.authorSener, Alper
dc.date.accessioned2025-01-27T20:39:23Z
dc.date.available2025-01-27T20:39:23Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Oxybutynin is a tertiary amine and has chemical similarities like prolamine sulfate. Protamine sulfate's effect on bacterial viability has been shown in some studies; however, there is scanty data regarding the effect of oxybutynin on bacterial viability. Accordingly, the aim of the present study was to investigate the effect of oxybutynin on bacterial viability. Methods: Twenty of Staphylococcus epidermidis (S. epidermidis) strains were isolated from patients who had catheter-associated urinary tract infection. These strains were exposed to 5 different concentrations of oxybutynin in tryptic soy broth (TSB) media (max: 5 mg/mL, min: 0.05 mg/mL). Quantitative growth patterns were measured by spectrophotometer. Under the same media conditions, biofilm production of individual strains was measured by Deighton's micromethod at the end of the 6-hour incubation period. Results: After the incubation period, weak and strong slime-producing bacteria groups were obtained and both groups' slime productions were extensively low at 5 mg/mL concentration of oxybutynin. Slime production of S. epidermidis was inversely correlated with oxybutynin concentrations. Conclusion: Although there was a dose-dependent reduction of biofilm production, there seemed to be no bactericidal effect of oxybutynin on S. epidermidis.
dc.identifier.doi10.1097/01.smj.0000305885.23903.71
dc.identifier.endpage239
dc.identifier.issn0038-4348
dc.identifier.issue3
dc.identifier.pmid18364650
dc.identifier.scopus2-s2.0-41849150016
dc.identifier.scopusqualityQ2
dc.identifier.startpage236
dc.identifier.urihttps://doi.org/10.1097/01.smj.0000305885.23903.71
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23937
dc.identifier.volume101
dc.identifier.wosWOS:000253868700013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofSouthern Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbiofilm
dc.subjectoxybutynin
dc.subjectStaphylococcus epidermidis
dc.titleOxybutynin effects on Staphylococcus epidermidis biofilm production
dc.typeArticle

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