The influence of dexmedetomidine on ischemic rat hippocampus

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dc.authoridMollaoglu, Hakan/0000-0002-6523-5607
dc.authoridSongur, Ahmet/0000-0002-6683-5495
dc.contributor.authorEser, Olcay
dc.contributor.authorFidan, Huseyin
dc.contributor.authorSahin, Onder
dc.contributor.authorCosar, Murat
dc.contributor.authorYaman, Mehmet
dc.contributor.authorMollaoglu, Hakan
dc.contributor.authorSongur, Ahmet
dc.date.accessioned2025-01-27T20:47:22Z
dc.date.available2025-01-27T20:47:22Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn our study, we evaluated the neuroprotective effects of dexmedetomidine on oxidantantioxidant systems, pro -inflammatory cytokine TNF-a and number of apoptotic neurons on hippocampus and dentate gyrus after transient global cerebral I/R injury. Eighteen rats divided into 3 groups, equally. Group I rats were used as shams. For group II and III rats, they were prepared for transient global cerebral ischemia using a four-vessel- occlusion model. 5 mL/kg/h 0.9% sodium chloride was infused to the Group II and 3 Pg/kg/h/5 ml dexmedetomidine was infused to the Group III for 2 h after I/R injury. The levels of MDA and NO and activities of SOD and CAT were measured in the left hippocampus tissue. The levels of TNF-a concentration were measured in the plasma. The number of apoptotic neurons was counted by TUNNEL method in histological samples of right hippocampus tissue. MDA and NO levels increased in Group II compared with Group I rats (p=0.002, p=0.002, respectively). In group III, MDA and NO levels decreased as compared to Group 11 (p=0.015, p=0.002, respectively). SOD and CAT activities increased in Group III as compared to Group II rats (p = 0.002, p = 0.002, respectively). The decrease in TNF-a levels of group III was significant as compared to group II (p=0.016). The number of apoptotic neurons in group III was lower than Group II rats. Our study showed that dexinedetomidine has a neuroprotective effect on hippocampus and dentate gyrus of rats after transient global cerebral I/R injury. (c) 2008 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.brainres.2008.04.045
dc.identifier.endpage256
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid18514174
dc.identifier.scopus2-s2.0-46349092911
dc.identifier.scopusqualityQ2
dc.identifier.startpage250
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2008.04.045
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24868
dc.identifier.volume1218
dc.identifier.wosWOS:000258016300024
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBrain Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcerebral
dc.subjectdexmedetomidine
dc.subjectinjury
dc.subjectischemia-reperfusion
dc.subjecthippocampus
dc.titleThe influence of dexmedetomidine on ischemic rat hippocampus
dc.typeArticle

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