Protective effect of coenzyme Q10 against bisphenol-A-induced toxicity in the rat testes

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dc.authoridAHMAD, Ejaz/0000-0003-1992-7941
dc.authoridKUM, Sadiye/0000-0001-6586-4596
dc.authoridYıldız, Mustafa/0000-0003-4128-8947
dc.authoridGules, Ozay/0000-0001-6170-1706
dc.authorideren, ulker/0000-0002-2451-8512
dc.authoridBoyacioglu, Murat/0000-0001-6952-8637
dc.contributor.authorGules, Ozay
dc.contributor.authorKum, Sadiye
dc.contributor.authorYıldız, Mustafa
dc.contributor.authorBoyacioglu, Murat
dc.contributor.authorAhmad, Ejaz
dc.contributor.authorNaseer, Zahid
dc.contributor.authorEren, Ulker
dc.date.accessioned2025-01-27T20:20:17Z
dc.date.available2025-01-27T20:20:17Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe present study was conducted to investigate the antioxidant, histomorphometric, histochemical, immunohistochemical, biochemical, and cytological effects of coenzyme Q10 (CoQ10) against bisphenol-A (BPA)-induced testicular toxicity in rats. A total of 40 adult male Wistar rats were divided into five equal groups. The control group remained untreated. The vehicle control group was administered corn oil (2 ml/kg/day), the BPA group was given BPA (100 mg/kg/day), the CoQ10 group was supplemented with CoQ10 (10 mg/kg/day), and the rats in the CoQ10-BPA group received CoQ10 (10 mg/kg/day) followed by BPA (100 mg/kg/day) 1 h later. The treatments were administered by oral gavage for 14 days. Results showed that the seminiferous tubule diameters (STDs) and seminiferous epithelium heights (SEHs) at stages VII-VIII and XII-XIV, number of undifferentiated embryonic cell transcription factor-1 (UTF-1) positive cells per tubule, UTF-1 positive tubules (%), plasma glutathione (GSH), and serum superoxide dismutase activities, testicular GSH activity and sperm viability (%) decreased whereas the number of terminal dUTP nick end labeling (TUNEL) positive cells per tubule, TUNEL positive tubules (%), testicular and serum malondialdehyde (MDA) levels, and the rate of mid-piece sperm abnormality increased in the BPA administered group. However, while the STDs at stages VII-VIII and XII-XIV, SEHs at stages VII-VIII, plasma GSH, and serum SOD activities increased, serum MDA level decreased in the CoQ10-BPA group. In conclusion, these results suggest a protective effect of CoQ10 against BPA-induced testicular toxicity in rats.
dc.description.sponsorshipScientific Research Projects of the University of Adnan Menderes [VTF-14001]; Aydin, Turkey
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Scientific Research Projects of the University of Adnan Menderes, project no. VTF-14001, Aydin, Turkey.
dc.identifier.doi10.1177/0748233719862475
dc.identifier.endpage481
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue7
dc.identifier.pmid31364507
dc.identifier.scopus2-s2.0-85070270539
dc.identifier.scopusqualityQ2
dc.identifier.startpage466
dc.identifier.urihttps://doi.org/10.1177/0748233719862475
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21649
dc.identifier.volume35
dc.identifier.wosWOS:000478097900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAntioxidant
dc.subjectbisphenol-A
dc.subjectcoenzyme Q10
dc.subjectsperm
dc.subjecttesticular histomorphometry
dc.subjectTUNEL
dc.titleProtective effect of coenzyme Q10 against bisphenol-A-induced toxicity in the rat testes
dc.typeArticle

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