Environmental exposures and RNA N6-Methyladenosine modified long Non-Coding RNAs

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dc.contributor.authorCayir, Akin
dc.date.accessioned2025-01-27T20:58:08Z
dc.date.available2025-01-27T20:58:08Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractRecent advances in the field of RNA modifications and long non-coding RNAs (lncRNAs) have provided substantial evidence on important biological functions. LncRNAs are defined as longer than 200 nucleotides which are not translated into proteins. The term epitranscriptome refers to all modifications in RNA types. Adenine-6 methylation (m(6)A) is the most common, dynamic and prominent modifications in coding and non-coding RNAs and has critical and previously unappreciated functional roles. Accumulation evidence indicated the association between RNA m6A modification and cancer and nonmalignant diseases. Recent studies reported that several lncRNAs includingMALAT1, MEG3, XIST, GAS5,andKCNK15-AS1are subject to m(6)A modification. It can be suggested that lncRNAs modified by m(6)A modification have substantive roles in diseases. Currently limited data are available regarding how environmental exposure affects m(6)A-modified lncRNAs. Furthermore, we do not know the interaction of environmental exposure and m(6)A-modified lncRNAs in development of adverse human health outcomes. Thus, in this systematic review, we aimed to present the data of the studies that reported a significant association between environmental exposure and expression/DNA methylation of m(6)A-modified long non-coding RNAs.
dc.identifier.doi10.1080/10408444.2020.1812511
dc.identifier.endpage649
dc.identifier.issn1040-8444
dc.identifier.issn1547-6898
dc.identifier.issue8
dc.identifier.pmid32924714
dc.identifier.scopus2-s2.0-85091017333
dc.identifier.scopusqualityQ1
dc.identifier.startpage641
dc.identifier.urihttps://doi.org/10.1080/10408444.2020.1812511
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26620
dc.identifier.volume50
dc.identifier.wosWOS:000570340600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofCritical Reviews in Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectLong non-coding RNAs
dc.subjectRNA modification
dc.subjectN6-methyladenosine
dc.subjectenvironmental exposure
dc.subjectbiomarker
dc.titleEnvironmental exposures and RNA N6-Methyladenosine modified long Non-Coding RNAs
dc.typeReview Article

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