Caffeic Acid Phenethyl Ester Alleviates Mesenteric Ischemia/Reperfusion Injury

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dc.authoridTeke, Zafer/0000-0001-8869-6476
dc.authoridYenisey, Cigdem/0000-0001-7693-641X
dc.contributor.authorTeke, Zafer
dc.contributor.authorBostanci, Erdal Birol
dc.contributor.authorYenisey, Cigdem
dc.contributor.authorSacar, Mustafa
dc.contributor.authorSimsek, Nilufer Genc
dc.contributor.authorAkoglu, Musa
dc.date.accessioned2025-01-27T20:41:03Z
dc.date.available2025-01-27T20:41:03Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on intestinal mucosal injury induced by superior mesenteric occlusion. Methods: This experimental study was conducted on 48 male Wistar albino rats. The animals were randomly allocated into four groups: (i) Sham-operated group, laparotomy without intestinal ischemia/reperfusion (IR) injury (n = 12); (ii) Sham + CAPE group, identical to group 1 except for CAPE treatment (10 mu mol/kg, intravenously) (n = 12); (iii) Intestinal IR group, 60 min of superior mesenteric ischemia followed by 3 hr of reperfusion (n = 12); and (iv) (IR + CAPE)-treated group, 10 mu mol/kg injection of CAPE intravenously 30 min before the reperfusion period (n = 12). We evaluated the degree of intestinal mucosal injury on a grading scale, histopathologically, and by measuring oxidative stress markers and antioxidant parameters, biochemically. Intestinal edema was estimated by using wet/dry weight ratios. The plasma proinflammatory cytokine levels were measured. Animal survival was observed up to one week. Results: Intestinal mucosal injury scores were significantly decreased with CAPE administration (p < .05). CAPE treatment significantly reduced oxidative stress markers in the intestinal tissues (p < .05) and the plasma proinflammatory cytokine levels (p <.05), and significantly increased antioxidant parameters in the intestinal tissues (p <.05). Intestinal edema was significantly alleviated by CAPE treatment (p < .05). The survival rates of CAPE-treated IR animals were significantly higher than IR-subjected rats (p < .05). Conclusion: This study clearly showed that CAPE treatment significantly alleviated the intestinal mucosal injury caused by superior mesenteric ischemia/reperfusion. Further clinical studies are required to clarify whether CAPE has a useful role in reperfusion injury during particular surgeries in which IR-induced organ injury occurs.
dc.identifier.doi10.3109/08941939.2012.677968
dc.identifier.endpage365
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6
dc.identifier.pmid23215792
dc.identifier.scopus2-s2.0-84870944916
dc.identifier.scopusqualityQ1
dc.identifier.startpage354
dc.identifier.urihttps://doi.org/10.3109/08941939.2012.677968
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23991
dc.identifier.volume25
dc.identifier.wosWOS:000311897200002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcaffeic acid phenethyl ester
dc.subjectischemia/reperfusion
dc.subjectmesenteric ischemia
dc.subjectreperfusion injury
dc.subjectoxidative stress
dc.subjectintestinal mucosal injury
dc.titleCaffeic Acid Phenethyl Ester Alleviates Mesenteric Ischemia/Reperfusion Injury
dc.typeArticle

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