Outcomes of retrograde intrarenal surgery in patients on anticoagulant or antiplatelet therapy: a multicenter matched case-control study by the RIRSearch Study Group

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dc.authorid0000-0002-0926-3005
dc.authorid0000-0001-6187-1940
dc.authorid0000-0002-0107-5843
dc.authorid0000-0003-2499-8947
dc.authorid0000-0001-7577-7955
dc.contributor.authorSimsekoglu, Muhammed Fatih
dc.contributor.authorOzman, Oktay
dc.contributor.authorSahin, Mehmet Fatih
dc.contributor.authorCakir, Hakan
dc.contributor.authorTeke, Kerem
dc.contributor.authorCinar, Onder
dc.contributor.authorAkgul, Murat
dc.date.accessioned2026-02-03T12:03:06Z
dc.date.available2026-02-03T12:03:06Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose This study aimed to assess the outcomes of various perioperative management strategies employed during retro-grade intrarenal surgery (RIRS) in patients receiving anticoagulant (AC) or antiplatelet (AP) therapy. Methods In this multicenter retrospective matched case-control study, we included patients with nephrolithiasis who received AC or AP therapy and underwent RIRS. The control group consisted of patients not receiving AC/AP therapy. Group 1 included patients who discontinued AC/AP treatment prior to RIRS, whereas Group 2 comprised patients who also discontinued AC/AP therapy but received bridging anticoagulation. The primary endpoints were surgical success and RIRS-related complications. These outcomes were assessed using non-contrast abdominopelvic computed tomography (CT) scans obtained during the first postoperative month. Results In the final analysis, Group 1 and Group 2 each comprised 50 patients, while the control group consisted of 56 patients. The mean age was 59.36 +/- 8.86 years in Group 1, 59.96 +/- 9.70 years in Group 2, and 56.59 +/- 11.56 years in the control group (p = 0.452). Surgical success was significantly lower in Group 2 (p = 0.026), and the need for auxiliary proce-dures was significantly higher in this group (p = 0.009). Although perioperative complications tended to be higher in Group 2 (p = 0.053), no statistically significant differences were observed in postoperative or overall complication rates. Conclusions Patients undergoing RIRS with bridging anticoagulation demonstrated lower surgical success rates and a higher need for auxiliary procedures. These findings underscore the importance of close monitoring and individualized periopera-tive management in this high-risk patient population.
dc.identifier.doi10.1007/s00345-025-06051-z
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue1
dc.identifier.pmid41148357
dc.identifier.scopus2-s2.0-105020304949
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00345-025-06051-z
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34971
dc.identifier.volume43
dc.identifier.wosWOS:001604488800005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofWorld Journal of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectUrolithiasis
dc.subjectEndourology
dc.subjectSurgery
dc.subjectStone
dc.subjectKidney
dc.titleOutcomes of retrograde intrarenal surgery in patients on anticoagulant or antiplatelet therapy: a multicenter matched case-control study by the RIRSearch Study Group
dc.typeArticle

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