Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[?2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(?2-CH2CH2NHNCC6H4)PdCl]2•C2H5OH complex

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authoridSenel, Mehmet/0000-0001-7366-4746
dc.contributor.authorAghatabay, Naz M.
dc.contributor.authorSomer, M.
dc.contributor.authorSenel, M.
dc.contributor.authorDulger, B.
dc.contributor.authorGucin, F.
dc.date.accessioned2025-01-27T21:00:19Z
dc.date.available2025-01-27T21:00:19Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe 1,6-bis(benzimidazol-2-yl)-3,4-dithiahexane (1) ligand and its palladium(H) chloride complex [(mu(2)-SCH2CH2NHNCC6H4)PdCl](2) center dot C2H5 OH (2) have been synthesised and characterised by spectroscopical methods. The crystal structure of the triclinic title compound (P-1 (no. 2), a = 879.6(l) pm, b = 984.4(l) pm, c = 1471.8(2) pm; a = 94.330(6)degrees, beta = 98.546(6)degrees, gamma = 99.258(7)degrees, Z = 2) was solved from X-ray single crystal diffraction data. In the binuclear complex, each palladium atom is coordinated in a slightly distorted square-planar arrangement by one nitrogen, two bridging sulphurs and one terminal chlorine atom. Molar conductivity, FT-Raman, FT-IR (mid-i.r., far-i.r.), H-1 and C-13 NMR spectra of the complex (2) have been recorded and show a good accordance with the square-planar geometry. The antimicrobial and antifungal activities of palladium(II) chloride, free ligand, its hydrochloride salt and the complex were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) the dilution method, against 10 bacteria and five yeast cultures. The results for the antibacterial from the disk diffusion method were assessed in side-by-side comparison with those for penicillin-g, ampicillin, cefotaxime, vancomycin, ofloxacin and tetracycline. Antifungal activities were referenced with nystatin, ketaconazole, and clotrimazole, commercial antifungal agents. The data from the dilution procedure were compared with gentamycin as antibacterial and nystatin as antifungal agent, respectively. In most cases, the compounds tested showed broad-spectrum (Gram positive and Gram negative) activities that were comparatively more active, or as potent as referenced pharmaceutical agents. The palladium complex has the potential to generate new kind of metabolites by displaying high affinities for most of the receptors compared with palladium chloride, free ligand and its hydrochloride salt. (c) 2007 Elsevier Masson SAS. All rights reserved.
dc.identifier.doi10.1016/j.ejmech.2007.01.011
dc.identifier.endpage1075
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue8
dc.identifier.pmid17350734
dc.identifier.scopus2-s2.0-34447576837
dc.identifier.scopusqualityQ1
dc.identifier.startpage1069
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2007.01.011
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26994
dc.identifier.volume42
dc.identifier.wosWOS:000249197600003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbimetallic
dc.subjectbridging
dc.subjectconductivity
dc.subjectdisk diffusion
dc.subjectFT-raman
dc.subjectsquare planar
dc.titleRaman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[?2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(?2-CH2CH2NHNCC6H4)PdCl]2•C2H5OH complex
dc.typeArticle

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