Synthesis of antibiotic-modified silica nanoparticles and their use as a controlled drug release system with antibacterial properties

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dc.contributor.authorYilmaz, Betul
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:24:35Z
dc.date.available2025-01-27T20:24:35Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, monodispersed silica nanoparticles were synthesized using the Stober method. The synthesized nanoparticles underwent a range of surface modifications and were converted to nanoparticles with drug release and antibacterial features. For modification, firstly -NH2 groups were created on the silica nanoparticle surface using (3-Aminopropyl)triethoxysilane (APTES). In the second stage, hexachlorocyclotriphosphazene (Phz) molecules were bound to the silica nanoparticle surfaces due to these amino groups. In the final stage of modification, the chloride groups in the hexachlorocyclotriphosphazene structure were modified with trimethoprim (TMP) and nanoparticles with antibacterial properties were obtained. The modified silica nanoparticles were characterized with scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), and Thermogravimetric analysis (TGA). The silica-based nanoparticles were used for release of rhodamine 6G, chosen as a model drug. As a result of the drug release studies, the modified silica nanoparticles were found to abide by the Korsmeyer-Peppas low power model and non-Fickian release mechanism as release model. Additionally, nanoparticles both loaded and not loaded with the model drug were determined to have antibacterial properties against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus bacteria.
dc.description.sponsorshipCanakkale Onsekiz Mart University [FYL-2019-3106]
dc.description.sponsorshipThis work was supported by the Canakkale Onsekiz Mart University under Grant [FYL-2019-3106].
dc.identifier.doi10.1080/10426507.2022.2049267
dc.identifier.endpage972
dc.identifier.issn1042-6507
dc.identifier.issn1563-5325
dc.identifier.issue9
dc.identifier.scopus2-s2.0-85126434343
dc.identifier.scopusqualityQ3
dc.identifier.startpage964
dc.identifier.urihttps://doi.org/10.1080/10426507.2022.2049267
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22284
dc.identifier.volume197
dc.identifier.wosWOS:000767620100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPhosphorus Sulfur and Silicon and The Related Elements
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSilica
dc.subjectnanoparticle
dc.subjectmodification
dc.subjectdrug delivery
dc.subjectantibacterial material
dc.titleSynthesis of antibiotic-modified silica nanoparticles and their use as a controlled drug release system with antibacterial properties
dc.typeArticle

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