Investigation of the effects of different doses of sugammadex on kidney histopathology in rabbits with acute renal failure

Basit Öğe Kaydı
dc.contributor.authorOzturk, Omur
dc.contributor.authorErbas, Mesut
dc.date.accessioned2025-01-27T20:20:43Z
dc.date.available2025-01-27T20:20:43Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: In our study, we hypothesised that using high doses, ie. 16 mg / kg sugammadex during general anesthesia after acute renal failure in rabbits would lead to a deteriorated renal histopathology due to the accumulation of rocuroniumsugammadex complex in the tubules. We aimed to investigate the effect of different doses of sugammadex (4 or 16 mg) on experimental kidney histopathology in rabbits with acute renal failure. Methodology: Eight New Zealand white adult male rabbits were used in the study. The rabbits were divided into 2 groups of four. The first group received low dose (4 mg) sugammadex and the second group received high dose (16 mg) sugammadex. Rabbits were administered 20 mg / kg of cisplatin intravenously 4 hours before general anesthesia and an acute renal failure model was established. After general anesthesia was applied, V-GEL (R) Rabbit was placed to all experimental animals to provide airway safety. All animals were manually ventilated using an anesthesia device. At the 25th min after induction, the rabbits in Group D received 4 mg / kg sugammadex iv, and the those in Group Y received 16 mg / kg sugammadex iv. At the end of the experiment, all experimental animals were sacrificed, and the kidneys were removed, and histopathologic examination was performed. Results: At the end of our study all experimental animals were sacrificed. There was no statistically significant difference between findings in the kidneys of animals of Group Y and Group D on histopathologic evaluation. Conclusion: The results of our study did not reveal any differences between the renal histopathological appearances of rabbits receiving 4 mg / kg or 16 mg / kg sugammadex IV.
dc.identifier.endpage46
dc.identifier.issn1607-8322
dc.identifier.issn2220-5799
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85069739543
dc.identifier.scopusqualityQ4
dc.identifier.startpage43
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21795
dc.identifier.volume23
dc.identifier.wosWOS:000474920300009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAnaesthesia Pain & Intensive Care
dc.relation.ispartofAnaesthesia Pain & Intensive Care
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAcute renal failure
dc.subjectSugammadex
dc.subjectRocuronium
dc.titleInvestigation of the effects of different doses of sugammadex on kidney histopathology in rabbits with acute renal failure
dc.typeArticle

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