The effect of sleeve gastrectomy on serum irisin levels in patients with morbid obesity

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dc.contributor.authorDemirpence, Mustafa
dc.contributor.authorYilmaz, Hamiyet
dc.contributor.authorColak, Ayfer
dc.contributor.authorYalcin, Hulya
dc.contributor.authorToprak, Burak
dc.contributor.authorTurkon, Hakan
dc.contributor.authorUgurlu, Levent
dc.date.accessioned2025-01-27T21:05:45Z
dc.date.available2025-01-27T21:05:45Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Irisin, a recently identified myokine, is associated with increased energy expenditure and has a potential role in obesity. Therefore, we investigated circulating irisin levels in morbidly obese patients undergoing sleeve gastrectomy (SG). Materials and methods: Thirty morbidly obese patients undergoing SG and 30 healthy subjects were included. All participants were evaluated at baseline and again at three months post-SG. Body weight and height, the lipid profile, and plasma glucose, HbA1c, insulin, and irisin levels were measured at each visit. Results: The two groups had similar mean age and sex distribution. Serum irisin was significantly lower in the morbidly obese subjects compared with the controls (p - 0.003) and negatively correlated with BMI, body weight, insulin levels, and HOMA-IR (p - 0.006, p = 0.011, p = 0.046, p = 0.048, respectively). When the morbidly obese patients were re-evaluated three months post-SG, their weight and BMI had significantly decreased (both p = 0.001). Similarly, the insulin, HbA1c, HDL-cholesterol, and HOMA-IR values significantly decreased (p - 0.001, p - 0.028, p - 0.006, and p - 0.001, respectively). However, irisin levels remained unchanged (p = 0,267). Conclusion: Although the irisin levels were significantly lower in the morbidly obese subjects, they did not change after SG-induced weight loss.
dc.identifier.doi10.5603/EP.a2016.0029
dc.identifier.endpage486
dc.identifier.issn0423-104X
dc.identifier.issue5
dc.identifier.pmid26884298
dc.identifier.scopus2-s2.0-84994613457
dc.identifier.scopusqualityQ3
dc.identifier.startpage481
dc.identifier.urihttps://doi.org/10.5603/EP.a2016.0029
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27781
dc.identifier.volume67
dc.identifier.wosWOS:000392136100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectirisin
dc.subjectobesity
dc.subjectbariatric surgery
dc.subjectsleeve gastrectomy
dc.subjectinsulin
dc.titleThe effect of sleeve gastrectomy on serum irisin levels in patients with morbid obesity
dc.typeArticle

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