Idiopathic Granulomatous Mastitis: A Consensus Report on Treatment and Follow-Up Approaches Based on the Turkish Clinical Classification

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dc.authoridÇetin, Kenan / 0000-0002-8616-9784
dc.contributor.authorEmiroğlu, Mustafa
dc.contributor.authorÇetin, Kenan
dc.contributor.authorYılmaz, Kerim Bora
dc.contributor.authorVelidedeoğlu, Mehmet
dc.contributor.authorGirgin, Sadullah
dc.contributor.authorAkcan, Alper
dc.contributor.authorAytaç, Özgür
dc.date.accessioned2025-05-29T02:57:39Z
dc.date.available2025-05-29T02:57:39Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The second consensus study on idiopathic granulomatous mastitis (IGM) aimed to establish treatment options based on the clinical classification proposed in the first consensus, standardize criteria for treatment discontinuation, and develop follow-up protocols. Method: A structured methodology, identical to the first consensus study, was employed. An 11-member working group of breast surgeons experienced in IGM from various clinics across the country was formed. The modified Delphi method was used, with a consensus threshold of 80% agreement. Results: Three voting rounds were conducted to develop the IGM treatment algorithm. In Round 1, observation was established as the first-line option for Type 1 disease (81%) and pregnancy/lactation cases (85%). Round 2 achieved consensus on systemic steroids (SS) as the first-line treatment for Type 3 cases (84%), combination therapies for resistant cases (82%), and reclassification of recurrent cases to guide treatment planning (94%). In Round 3, consensus was reached on the use of immunosuppressive therapy (IMT) for cases where steroids are contraindicated in Type 3 (81%), the use of IMT for resistant cases (93%), avoiding surgery as the first-line option for Type 1 cases (81%), and requiring complete clinical and radiological response before discontinuing treatment (81%). However, no consensus was reached on the first-line treatment for Type 2 disease. Conclusion: This consensus study successfully developed a treatment algorithm for IGM, prioritizing observation for Type 1 disease and cases involving pregnancy or lactation, and recommending systemic steroids (SS) and immunosuppressive therapies for Type 3 cases. The findings underscore the critical importance of achieving complete clinical and radiological remission before discontinuing treatment. However, the lack of consensus on the treatment of Type 2 disease highlights the need for further research into this challenging subtype.
dc.identifier.doi10.1159/000544967
dc.identifier.issn1661-3791
dc.identifier.issn1661-3805
dc.identifier.pmid40860773
dc.identifier.scopus2-s2.0-105003849254
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1159/000544967
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30122
dc.identifier.wosWOS:001468830200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofBreast Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectIdiopathic granulomatous mastitis
dc.subjectTurkish Clinical Classification
dc.subjectConsensus study
dc.subjectTreatment algorithm
dc.subjectModified Delphi Method
dc.titleIdiopathic Granulomatous Mastitis: A Consensus Report on Treatment and Follow-Up Approaches Based on the Turkish Clinical Classification
dc.typeArticle

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