Garlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure

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dc.authoridSener, Goksel/0000-0001-7444-6193
dc.authoridYegen, Berrak/0000-0003-0791-0165
dc.contributor.authorDeniz, Mustafa
dc.contributor.authorSener, Goksel
dc.contributor.authorErcan, Feriha
dc.contributor.authorYegen, Berrak C.
dc.date.accessioned2025-01-27T21:00:15Z
dc.date.available2025-01-27T21:00:15Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractChronic renal failure (CRF) is associated with oxidative stress that promotes production of reactive oxygen species and cytokine release. We aimed to investigate the possible protective and antioxidant effects of aqueous garlic extract (AGE) in a rat model of CRF. Male Sprague-Dawley rats were randomly assigned as either CRF group with 5/6 reduction in the renal mass or sham-operated control group. CRF group received either saline or AGE (250 mg/kg/day/1 mL) orally for 3 weeks. At the end of the 3 weeks, rats were decapitated and trunk blood was collected. Creatinine, blood urea nitrogen (BUN) and lactate dehydrogenase (LDH) activity, and TNF-alpha alpha and IL-1 beta beta levels were measured in the serum samples, while malondialdehyde (MDA), glutathione (GSH) levels, and myeloperoxidase (MPO) activity were determined in the kidney, lung, and heart samples. CRF caused significant decreases in tissue GSH, which were accompanied with significant increases in MDA levels and MPO activities, while the circulating levels of the LDH activity, creatinine, BUN, TNF-alpha alpha, and IL-1 beta beta were elevated. AGE treatment alleviated CRF-induced oxidative changes in the injured tissues, while CRF-induced elevations in the blood levels of the pro-inflammatory cytokines and LDH were reduced. In conclusion, CRF-induced oxidative tissue injury occurs via the activation of pro-inflammatory mediators and by neutrophil infiltration into tissues and that the protective effects of garlic on CRF-induced injury can be attributed to its ability to inhibit neutrophil infiltration and pro-inflammatory mediators. These findings suggest that garlic, as a supplementary to diet, may have a potential therapeutic use in delimitating the systemic oxidant effects of CRF on remote organs.
dc.identifier.doi10.3109/0886022X.2011.589952
dc.identifier.endpage725
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7
dc.identifier.pmid21787163
dc.identifier.scopus2-s2.0-79960778999
dc.identifier.scopusqualityQ2
dc.identifier.startpage718
dc.identifier.urihttps://doi.org/10.3109/0886022X.2011.589952
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26978
dc.identifier.volume33
dc.identifier.wosWOS:000293096800011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectGarlic
dc.subjectchronic renal failure
dc.subjectoxidative damage
dc.subjectneutrophils
dc.subjectantioxidant
dc.titleGarlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure
dc.typeArticle

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