Effect of casein phosphopeptide amorphous calcium fluoride phosphate and calcium glycerophosphate on incisors with molar-incisor hypomineralization: A cross-over, randomized clinical trial

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dc.contributor.authorSezer, Berkant
dc.contributor.authorTugcu, Nihan
dc.contributor.authorCaliskan, Cansu
dc.contributor.authorDurmus, Basak
dc.contributor.authorKupets, Tatiana
dc.contributor.authorBekiroglu, Nural
dc.contributor.authorKargul, Betul
dc.date.accessioned2025-01-27T20:24:37Z
dc.date.available2025-01-27T20:24:37Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBACKGROUND: Within the scope of minimally invasive dentistry, the use of different biocompatible remineralization agents on incisors affected by molar-incisor hypomineralization (MIH) gains importance. OBJECTIVE: To evaluate the effect of casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) and calcium glycerophosphate (CaGP) in mineral density (MD) of white/creamy and yellow/brown demarcated opacities on incisors affected by MIH by means laser fluorescence (LF). METHODS: As a cross-over, randomized trial, twenty-two children with 167 incisors affected by MIH were recruited and randomly assigned to one of the two different agents and crossed over to other agents with two weeks washout in between. Incisors were examined by using LF at all before and after three months periods. RESULTS: The results of the paired t-tests for determining the period effect between the baseline findings showed significant difference in white/creamy and yellow/brown demarcated opacities of LF values for both groups (p < 0.05). The difference between both groups according to after categorization of 20% increasing in MD in the percent of change before and after application on LF values; was not found statistically significant in white/creamy (p = 0.970) and yellow/ brown (p = 0.948) opacities. CONCLUSIONS: The primary outcome was CPP-ACFP and CaGP had a positive effect in decreasing hypomineralization on MIH-affected enamel for three months period.
dc.identifier.doi10.3233/BME-211371
dc.identifier.endpage335
dc.identifier.issn0959-2989
dc.identifier.issn1878-3619
dc.identifier.issue4
dc.identifier.pmid35253727
dc.identifier.scopus2-s2.0-85134526983
dc.identifier.scopusqualityQ4
dc.identifier.startpage325
dc.identifier.urihttps://doi.org/10.3233/BME-211371
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22296
dc.identifier.volume33
dc.identifier.wosWOS:000827339500007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIos Press
dc.relation.ispartofBio-Medical Materials and Engineering
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMolar incisor hypomineralization
dc.subjectminimally invasive dentistry
dc.subjectremineralization
dc.subjectpreventive dentistry
dc.subjectcasein phosphopeptide amorphous calcium fluoride phosphate
dc.subjectcalcium glycerophosphate
dc.titleEffect of casein phosphopeptide amorphous calcium fluoride phosphate and calcium glycerophosphate on incisors with molar-incisor hypomineralization: A cross-over, randomized clinical trial
dc.typeArticle

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