Effects of tenoxicam in experimental corrosive esophagitis model

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dc.contributor.authorErbas, M.
dc.contributor.authorKiraz, H. A.
dc.contributor.authorKucuk, A.
dc.contributor.authorTopaloglu, N.
dc.contributor.authorErdem, H.
dc.contributor.authorSahin, H.
dc.contributor.authorToman, H.
dc.date.accessioned2025-01-27T20:29:09Z
dc.date.available2025-01-27T20:29:09Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractEsophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Canakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use.
dc.identifier.doi10.1111/dote.12197
dc.identifier.endpage257
dc.identifier.issn1442-2050
dc.identifier.issue3
dc.identifier.pmid24602009
dc.identifier.scopus2-s2.0-84926419987
dc.identifier.scopusqualityQ2
dc.identifier.startpage253
dc.identifier.urihttps://doi.org/10.1111/dote.12197
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22843
dc.identifier.volume28
dc.identifier.wosWOS:000352501600009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press Inc
dc.relation.ispartofDiseases of The Esophagus
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcaustic esophageal burn
dc.subjecttenoxicam
dc.subjecttreatment
dc.titleEffects of tenoxicam in experimental corrosive esophagitis model
dc.typeArticle

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