A schiff base sensor selective to anions, biological activity, and spectral studies

In this study, synthesis, characterization, anion sensor properties, and DNA binding of a benzothiazole-based Schiff base 4-bromo-2-((6-methoxybenzo[d]thiazol-2-ylimino)methyl)phenol have been investigated. The structure of the Schiff base was revealed with elemental analysis and spectroscopic methods. The colorimetric and fluorescent anion sensor properties of the Schiff base in DMSO were investigated by adding an equivalent amount of anions. In this context, the solution containing Schiff base had a color change after the addition of F-, CN-, AcO-, H2PO4 - and OH- anions, while the color change was not observed with the addition of Br-, I-, SCN-, ClO4 - and HSO4 - anions. The anion-binding power of the compound was found to be F- >OH- >AcO- >CN- >H2PO4 - using UV-Vis spectrophotometry, respectively. The antimicrobial activity of the compound was investigated against some microorganisms. The compound showed activity against bacteria and yeast. Schiff base showed a similar effect against both bacteria and yeast. Interactions between the compound and CT-DNA were studied with UV-Vis spectra. The UV-Vis experiment results confirm that the Schiff base binds to CT-DNA in an intercalative mode. The compound did not show any cleavage effect on SC DNA as hydrolytic and oxidative. © 2018, Turkish Chemical Society. All rights reserved.