Targeted delivery of phytochemicals via nanocarriers: Emerging strategies for psoriasis and acne

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dc.authorid0000-0003-4056-1673
dc.contributor.authorDarbandy, Zahra Jalayeri
dc.contributor.authorOroojalian, Fatemeh
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorKarav, Sercan
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2026-02-03T12:02:33Z
dc.date.available2026-02-03T12:02:33Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPsoriasis and acne are prevalent dermatological disorders often managed with conventional therapies, which present limitations in efficacy, safety, and long-term outcomes. Recently, increasing attention has been directed toward the integration of phytoconstituents, bioactive compounds derived from medicinal plants, into nanocarrier-based drug delivery systems as a novel therapeutic strategy. Phytochemicals possess well-documented antioxidant, anti-inflammatory, and wound-healing properties, and generally offer favorable a safety profile compared to synthetic agents. Incorporated of these natural compounds into nanocarriers enhances their therapeutic potential by improving skin penetration, enabling controlled drug release, facilitating targeted delivery, and reducing dosing frequency. This review highlights recent advances in the use of nanotechnology to optimize the delivery and efficacy of phytoconstituents for treating psoriasis and acne. It also discusses the mechanistic insights, therapeutic outcomes, formulation challenges, and translational hurdles associated with the clinical application of these nano-herbal systems. Continued research and development are essential to address formulation stability, scaling processes, regulatory compliance, and clinical validation, thereby facilitating the commercialization of effective and safe phyto-nanocarrier therapies in dermatology
dc.identifier.doi10.1016/j.sajb.2025.11.027
dc.identifier.endpage85
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-105023195702
dc.identifier.scopusqualityQ1
dc.identifier.startpage68
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2025.11.027
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34795
dc.identifier.volume189
dc.identifier.wosWOS:001631119700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectPhytoconstituents
dc.subjectNanocarriers
dc.subjectAcne
dc.subjectPsoriasis
dc.subjectHerbal drug delivery
dc.subjectNanoformulations
dc.titleTargeted delivery of phytochemicals via nanocarriers: Emerging strategies for psoriasis and acne
dc.typeArticle

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