Minor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes

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dc.authoridince, bahri/0000-0001-5000-9845
dc.authoridGuloksuz, Sinan/0000-0002-6626-1874
dc.contributor.authorInce, Bahri
dc.contributor.authorGuloksuz, Sinan
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorOral, Esat Timuin
dc.contributor.authorAlpkan, Latif Ruhsat
dc.contributor.authorAltinoz, Meric A.
dc.date.accessioned2025-01-27T20:16:31Z
dc.date.available2025-01-27T20:16:31Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: There exist studies indicating that bipolar disorder (BD) associates with changes in brain blood flow. Human brain with its high demand to oxygen constitutes 2% of the Loral body weight, while it receives 20% of cardiac output, a and 13;-,Ylobin chains of hemoglobin were recently found in neural tissues, yet no study has questioned blood hemoglobins in BD. Methods: A total of 120 euthymic BD patients (40 males and SO females) were analyzed via high performance liquid chromatography (1-IPLC) to measure minor hemoglobin levels, which were statistically compared with disease characteristics. Results: Minor hemoglobins HbA2 and HbF associated positively with episode density as a measure of disease severity in BD. An increased level of HbA2 meant significantly less postpartum episodes in child bearing women. HbF levels were higher in patients with a positive family history of any psychotic disorder. Sum of HbA2 and HbF correlated with episode density with a stronger significance (p <0001) supporting intermittent hypoxia hypothesis in 130. Limitations: The study was conducted only on euthymic patients to avoid likely bigger exogenous effects such as electro-convulsive therapy and diverse drug regimes, yet larger comparative studies are needed to support our current findings. Conclusions: Higher HbA2 and HbF in more severe bipolar disorder may be compensations against intermittent hypoxias in BD. HbA2 increases following myocardial angina and in mountain dwellers, which may indicate protective roles in extreme conditions. HbF increase may act more as a maladaptation or emerge via haplotypal associations of BD genes and gamma-globin locus at 11p15.5. (C) 2013 Elsevier B.V. All rights reserved,
dc.identifier.doi10.1016/j.jad.2013.06.042
dc.identifier.endpage408
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.issue1
dc.identifier.pmid23856286
dc.identifier.scopus2-s2.0-84888639256
dc.identifier.scopusqualityQ1
dc.identifier.startpage405
dc.identifier.urihttps://doi.org/10.1016/j.jad.2013.06.042
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21268
dc.identifier.volume151
dc.identifier.wosWOS:000324039500057
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Affective Disorders
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBipolar disorder
dc.subjectHemoglobin A2
dc.subjectFetal hemoglobin
dc.subjectIntermittent hypoxia
dc.subjectEpisode density
dc.subjectPostpartum episode
dc.titleMinor hemoglobins HbA2 and HbF associate with disease severity in bipolar disorder with a likely protective role of HbA2 against post-partum episodes
dc.typeArticle

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