Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Staphylococcus Aureus

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dc.authoridToka Ozer, Turkan/0000-0001-6125-2031
dc.contributor.authorDurmaz, Suleyman
dc.contributor.authorKiraz, Asli
dc.contributor.authorOzer, Turkan Toka
dc.contributor.authorPercin, Duygu
dc.date.accessioned2025-01-27T20:38:57Z
dc.date.available2025-01-27T20:38:57Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractStaphylococcus aureus is one of the most frequently isolated pathogens in community and hospital-acquired infections. Macrolidelincosamide- streptogramin B (MLSB) group antibiotics have frequently been preferred. In this study, it was aimed to determine MLSB group antibiotics resistance phenotypes observed in S. aureus strains. A total of 182 S. aureus strains were included in the study. Methicillin resistance was assessed using the cefoxitin (30 mu g) disc, MLSB resistance phenotypes were assessed using D zone test with erythromycin (15 mu g mu) and clindamycin (2 mu g) discs according to the Clinical and Laboratory Standards Institute (CLSI) recommendations. Of the strains included in the study, 38 (20.9%) methicillin-resistant S. aureus (MRSA) and 144 (79.1%) methicillin-susceptible S. aureus (MSSA) were identified. MLSB resistance phenotype was found in 65 (35.7%) strains. MLSB resistance was found 84% in MRSA strains and 23% in MSSA strains: There was statistically significant between MRSA and MSSA strains. Constitutional MLSB resistance was found higher in MRSA strains (71%) and however, in MSSA strains was higher inducibleMLSB resistance (16.5%). It is suggested that, using the D test method in routine antibiotic susceptibility testing and determining resistance phenotypes in microbiology laboratories is the right approach and may play an important role in the prevention of treatment failure according to the substantial proportion of inducible resistance MLSB resistance observed.
dc.identifier.doi10.15197/sabad.1.11.75
dc.identifier.endpage220
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84920468989
dc.identifier.scopusqualityN/A
dc.identifier.startpage217
dc.identifier.urihttps://doi.org/10.15197/sabad.1.11.75
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23811
dc.identifier.volume11
dc.identifier.wosWOS:000421938200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectStaphylococcus aureus
dc.subjectMLSB resistance
dc.subjectD test
dc.subjectmethicillin resistance
dc.titleMacrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Staphylococcus Aureus
dc.title.alternativeStaphylococcus aureus suşlarında makrolid-linkozamid-streptogramin B direnç fenotipleri
dc.typeArticle

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