Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.contributor.authorAghatabay, Naz M.
dc.contributor.authorBas, A.
dc.contributor.authorKircali, A.
dc.contributor.authorSen, G.
dc.contributor.authorYazicioglu, M. B.
dc.contributor.authorGuecin, F.
dc.contributor.authorDuelger, B.
dc.date.accessioned2025-01-27T20:52:22Z
dc.date.available2025-01-27T20:52:22Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSeries of new mixed aza-oxo-thia macrocyclic ligands 1,9(2,6)-ditriazina-2,8,10,16-tetraaza-3,7,11,15-tetraoxo-5,13-dithia-cyclohexadecaphan-1(4),9(4)-diphenyl (L-1); 1,10(2,6)-ditriazina-2,9,11,18-tetraaza-3,8,12, 17-tetraoxo-5,6,14,15-tetrathia-cyclooctadecaphan-1(4),10(4)-diphenyI (L-2); 1,11(2,6)-ditriazina-2,10,12,20-tetraaza-3,9,13,19-tetraoxo-6,16-dithia-cyclocosa-phan-1(4),11(4)-diphenyl (L-3); 1,12(2,6)-ditriazina-2,11,13,22-tetraaza-3,10,14,21-tetraoxo-6,7,17,18-tetrathia-cyclodocosaphan-1(4),12(4)-diphenyl (L-4) were synthesised. The structural features of the compounds have been studied by elemental analyses, Mass, FT-Raman, FT-IR, H-1 and C-13 NMR spectroscopy. The antimicrobial activities of the ligands were evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against several bacteria and yeast cultures. The obtained results from both methods were assessed in side-by-side comparison with commercial antibacterial and antifungal agents. In most cases, the compounds show strong antifungal activity in the comparison tests. Cytotoxic activities of the ligands against two different human cancer cell lines, stomach (23132/87) and lung (A549) were determined by MTT assay. DNA fragmentation assay tested cell lines were used to analyze the DNA ladder formation which is a characteristic of apoptotic cell death. The binding of the ligands with calf thymus DNA (CT-DNA) has also been investigated by absorption spectroscopy. (C) 2009 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipFatih University Scientific Research Centre [P50020702]
dc.description.sponsorshipWe would like to extend our gratitude to the Fatih University Scientific Research Centre for their financial support under project-P50020702.
dc.identifier.doi10.1016/j.ejmech.2009.07.003
dc.identifier.endpage4689
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue11
dc.identifier.pmid19700225
dc.identifier.scopus2-s2.0-70349769167
dc.identifier.scopusqualityQ1
dc.identifier.startpage4681
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2009.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25747
dc.identifier.volume44
dc.identifier.wosWOS:000271225800050
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectApoptotic
dc.subjectCT-DNA
dc.subjectCytotoxic
dc.subjectFT-Raman
dc.subjectInhibitory
dc.subjectMacrocyclic
dc.subjectYeast cultures
dc.titleSynthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds
dc.typeArticle

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