Effectiveness of Duct Excision Procedures in Detecting Preneoplastic and Malignant Lesions in Pathological Nipple Discharge: A Retrospective Cohort Study

Basit Öğe Kaydı
dc.authorid0000-0001-8427-9974
dc.contributor.authorAta, Batuhan
dc.contributor.authorKaradag, Volkan
dc.contributor.authorCetin, Kenan
dc.date.accessioned2026-02-03T12:00:41Z
dc.date.available2026-02-03T12:00:41Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and Aims: Nipple discharge ranges from benign to pathological, indicating inflammation or epithelial proliferation. In 5%-28% of cases, pathological nipple discharge (PND) may indicate breast carcinoma. Our objective was to evaluate the detection rates of malignant and high-risk lesions (HRL) in patients undergoing major duct excision (MDE) and microductectomy for diagnostic purposes due to PND and to assess the need for re-excision in malignancies. Method: Patients diagnosed with PND between October 2015 and December 2023 underwent duct excision procedures after physical, imaging, and histopathological examinations, if necessary. Patients with malignancies detected by histopathological evaluation underwent oncological procedures and were excluded from the study. Results: Among 118 patients, 80 underwent microductectomy and 38 underwent MDE. Intraductal lesions (ILs) were detected in 62% of cases, with higher detection rates in the microductectomy group (69% vs. 47%, p < 0.03). Of these lesions, 23 were classified as HRL (24% in the microductectomy group vs. 11% in the MDE group, p = 0.09). Malignancy was detected in 16 patients (13.6%), with a higher rate in the MDE group (18% vs. 11%, p = 0.3). Five patients required re-excision for clear surgical margins, with no significant difference between the groups (microductectomy: n = 2; MDE: n = 3, p = 0.3). Conclusion: The malignancy detection rate was slightly higher in the MDE group; however, this difference was not statistically significant. Similarly, there was no significant difference in the need for re-excision. Microductectomy, which preserves lactation function, may be preferred for premenopausal individuals or those considering future pregnancies when clinical presentation supports single-duct involvement. The differing distribution of IL and HRL between procedures reflects the pathology associated with their respective clinical indications rather than a difference in diagnostic performance.
dc.identifier.doi10.1155/tbj/2467046
dc.identifier.issn1075-122X
dc.identifier.issn1524-4741
dc.identifier.issue1
dc.identifier.pmid41438122
dc.identifier.scopus2-s2.0-105024887636
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/tbj/2467046
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34663
dc.identifier.volume2025
dc.identifier.wosWOS:001639704600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBreast Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectbreast carcinoma
dc.subjectduct excision
dc.subjectintraductal lesions
dc.subjectmicroductectomy
dc.subjectnipple discharge
dc.titleEffectiveness of Duct Excision Procedures in Detecting Preneoplastic and Malignant Lesions in Pathological Nipple Discharge: A Retrospective Cohort Study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu